Document Detail


Assessment of placental vascularization by three-dimensional power Doppler "vascular biopsy" in normal pregnancies.
MedLine Citation:
PMID:  16158469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To describe the evolution of placental vascularization during a normal course of gestation and the blood flow 3D power Doppler indices obtained by "placental vascular biopsy." METHODS: A prospective study was carried out on 99 normal singleton pregnancies from 14 to 40 weeks. Placental vascularization was evaluated by 3D power Doppler ("placental biopsy"). The spherical volume acquired was analyzed using the VOCAL imaging program (Virtual Organ Computer-aided AnaLysis). Three vascular indices, vascularization index (VI), flow index (FI), and vascularization-flow index (VFI), were calculated. Equations and regression coefficients for placental volume and vascular indices (VI, FI, VFI) of the placental biopsy were calculated according to gestational age. Relationships between 3D placental flow indices and fetal growth parameters: biparietal diameter, head circumference, abdominal circumference, femur length, estimated fetal body weight, maximum systolic velocity (US), and resistance index in the umbilical artery (URI) were evaluated by calculating their correlation coefficients. RESULTS: All 3D Doppler indices had a significant relationship with gestational age. The most significant relationship was observed for FI, and the least significant for VI (r=0.58, r=0.29, respectively; P<0.01 for both). The FI increased linearly with gestation, whereas the VI showed a dispersion of values with a plateau from the 30th week onwards and a decrease from 37th week to the end of pregnancy. The VFI behaved as a combination of both VI and FI indices from which it was derived. All 3D Doppler indices were significantly related to fetal biometric parameters, except VI and fetal weight. A significant correlation was observed between 3D Doppler indices and maximum systolic velocity and URI. CONCLUSIONS: 3D power Doppler technique of placental vascular "biopsy" is an appropriate tool for routine evaluation of the human placental vascular tree during gestation. 3D Doppler indices change as pregnancy progresses and are significantly related with fetal biometry and umbilical artery Doppler velocimetry.
Authors:
Luis Tadeo Merce; Maria J Barco; Santiago Bau; Sanja Kupesic; Asim Kurjak
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Croatian medical journal     Volume:  46     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  765-71     Citation Subset:  IM    
Affiliation:
International Ruber Hospital, 17, 28035-Madrid, Spain. ltmerce@meditex.es
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiovascular System / ultrasonography*
Diagnostic Tests, Routine
Endothelium, Vascular / ultrasonography*
Female
Gestational Age
Humans
Placental Circulation / physiology*
Pregnancy
Prospective Studies
Ultrasonography, Doppler*
Ultrasonography, Prenatal / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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