Document Detail

Assessment of the perinatal effects of maternal ingestion of Solanum malacoxylon in rats.
MedLine Citation:
PMID:  12507660     Owner:  NLM     Status:  MEDLINE    
A perinatal study was performed to verify the toxic effects of Solanum malacoxylon, which contains a glycoside conjugated to Vitamin D(3). In the gestational study, female rats received S. malacoxylon leaves in the diet at 0, 0.1, 0.2, 0.5, and 1% from days 6 to 21 of pregnancy. At 21 days of gestation, blood samples were taken from the dams for evaluation of serum Ca and P. A laparotomy was performed and the rats were examined for standard parameters of reproductive performance. Fetuses were examined for skeletal changes and histopathologic evaluation. In the second trial, dams were fed diets containing 0 or 0.1% S. malacoxylon leaves during the gestation and lactation periods. After weaning, all animals were euthanized and biochemical and histopathologic evaluations were performed. The biochemical evaluation showed increase in Ca and P levels in females from all experimental groups; however, this effect did not occurred in a dose-related manner. Pups from dams exposed during gestation and lactationi also showed increased Ca and P levels. Fetal data suggested a delay of fetal development manifested by decreased body weight and skeletal alterations. There was also a reduction in live fetuses. Histopathologic study revealed alterations of the soft tissue in litters from dams given 1% dietary S. malacoxylon during pregnancy and 0.1% during pregnancy and lactation. These findings support our hypothesis that Vitamin D(3) glycoside crosses the placenta and suggests milk transfer of this substance.
Silvana Lima Górniak; Paulo Cesar Maiorka; Paulo Cesar Raspantini; Rosana Hosomi; Ana Paula Moraes; Maria Lucia Zaidan Dagli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  17     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2002-12-31     Completed Date:  2003-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Inc.
Department of Pathology, Faculty of Veterinary Medicine, Research Center for Veterinary Toxicology (CEPTOX), University of São Paulo, São Paulo, SP, Brazil.
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MeSH Terms
Abnormalities, Drug-Induced*
Administration, Oral
Body Weight / drug effects
Bone Development / drug effects
Bone and Bones / drug effects,  embryology
Calcium / blood
Cholecalciferol / metabolism
Dose-Response Relationship, Drug
Embryonic and Fetal Development / drug effects
Lactation / drug effects
Litter Size / drug effects
Phosphorus / blood
Plant Leaves / toxicity
Plants, Toxic
Rats, Wistar
Reproduction / drug effects*
Solanaceous Alkaloids / administration & dosage,  metabolism,  toxicity*
Solanum / chemistry,  toxicity*
Toxicity Tests
Reg. No./Substance:
0/Solanaceous Alkaloids; 67-97-0/Cholecalciferol; 7440-70-2/Calcium; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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