Document Detail


Assessment of peak oxygen consumption, lactate and ventilatory thresholds and correlation with resting and exercise hemodynamic data in chronic congestive heart failure.
MedLine Citation:
PMID:  2330899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the clinical value of respiratory gas analysis during exercise, oxygen consumption (VO2) at peak exercise and at lactate and ventilatory threshold was assessed in 34 patients with chronic heart failure who underwent maximal exercise testing with expiratory gas monitoring and serial determinations of mixed venous lactate and hemodynamics by Swan-Ganz catheterization. A lactate threshold, defined as the point of abrupt increment of blood lactate, could be identified in every patient; the ventilatory threshold, detected on the basis of the respiratory changes, was found in 26 patients (77%). Lactate and ventilatory thresholds were significantly related to each other (r = 0.94; p less than 0.001) and to peak VO2 (r = 0.89; p less than 0.001 in both). Among the resting hemodynamic measurements, peak VO2 was significantly related only to total pulmonary resistances (r = -0.35). Among the parameters at maximal exercise, it was positively related to cardiac index, stroke work, stroke volume index and mean arterial pressure (r = 0.89, 0.74, 0.74 and 0.56, respectively) and inversely related to systemic vascular and total pulmonary resistances (r = -0.74 and -0.63). Using multivariate stepwise regression analysis only maximal cardiac index and, to a lesser degree, total pulmonary resistance were related to peak VO2. Similar correlations were found between the hemodynamics and the lactate and ventilatory threshold. Thus, peak VO2, lactate and ventilatory thresholds can be detected in most patients with chronic heart failure. These parameters are highly correlated to each other and bear similar relations to the hemodynamic response to exercise. The cardiac index is the main central hemodynamic determinant of exercise capacity.
Authors:
M Metra; R Raddino; L Dei Cas; O Visioli
Related Documents :
21200339 - Intermittent-sprint performance and muscle glycogen following 30 h sleep deprivation.
23873309 - Low heart rates predict incident atrial fibrillation in healthy middle-aged men.
16046339 - Effect of incremental exercise on initiation and movement times in a choice response, w...
17286209 - The declining phase of lactation: peripheral or central, programmed or pathological?
10090459 - Substantial influence of level of endurance capacity on the association of perceived ex...
23010159 - Vasoreactivity before and after handgrip training in chronic heart failure patients.
9151119 - Comparative stereological study on zonation and cellular composition of adrenal glands ...
24755869 - Test-retest reliability and sensitivity of the concept2 dyno dynamometer: practical app...
25477289 - Impact of supervised exercise rehabilitation on daily physical activity of cardiopulmon...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  65     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-05-30     Completed Date:  1990-05-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1127-33     Citation Subset:  AIM; IM    
Affiliation:
Cattedra di Cardiologia, Universita' di Brescia, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Exercise Test
Heart Failure / metabolism,  physiopathology*
Hemodynamics / physiology*
Humans
Lactates / blood
Male
Middle Aged
Monitoring, Physiologic
Oxygen Consumption / physiology
Pulmonary Gas Exchange / physiology
Respiration / physiology*
Respiratory Function Tests
Chemical
Reg. No./Substance:
0/Lactates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of dobutamine on skeletal muscle metabolism in patients with congestive heart failure.
Next Document:  Decreased coronary vasodilatory capacity in hypertrophic cardiomyopathy determined by split-dose tha...