Document Detail

Assessment of patent ductus arteriosus shunting using diastolic pressure analysis.
MedLine Citation:
PMID:  758389     Owner:  NLM     Status:  MEDLINE    
Ductal shunting significantly affected the time necessary for aortic diastolic pressure to fall to one-half an initially selected value (t1/2). Fourteen premature infants with clinical evidence of left-to-right ductal shunting had a mean t1/2 of 277 msec (range 133 to 383 msec) compared with a mean t1/2 of 455 msec (range 332 to 567 msec) in 14 neonates with no clinical evidence of ductal shunting (P less than 0.01). Seven older infants with ductal shunting confirmed at cardiac catheterization had a mean t1/2 of 360 msec (range 240 to 392 msec). Infant catheterization data and animal studies are suggestive of an inverse relationship between the magnitude of shunt and the t1/2. The t1/2 determined by diastolic pressure analysis is a useful method for serial evaluation of ductus arteriosus shunting.
J M Milstein; T A Riemenschneider; B W Goetzman; L George; R P Wennberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  94     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-02-21     Completed Date:  1979-02-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Ductus Arteriosus, Patent / physiopathology*
Infant, Newborn
Infant, Premature, Diseases / physiopathology*
Myocardial Contraction*
Pulmonary Circulation
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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