Document Detail

Assessment of pancreatic blood flow with positron emission tomography and oxygen-15 water.
MedLine Citation:
PMID:  1797067     Owner:  NLM     Status:  MEDLINE    
Dynamic positron emission tomography (PET) was performed following an intravenous bolus injection of 15O-water for the assessment of regional pancreatic blood flow in 4 normal volunteers and 11 patients with pancreatic cancer. The regional pancreatic blood flow index (PFI) was calculated by the autoradiographic method assuming the time-activity curves of the aorta as an input function. The mean PFI value was 0.514 +/- 0.098 in the normal pancreas but it was decreased in pancreatic cancer (0.249 +/- 0.076) (p less than 0.01), with a concomitant decrease in the pancreatic region distal to the tumor. On the other hand, in cases with body or tail cancer, the part proximal to the tumor (nontumorous head region) had a similar PFI value (0.554 +/- 0.211) to that of normal cases. Thus, a PET study with 15O-water permits quantitative assessment of pancreatic blood flow which decreased in both pancreatic cancer and concomitant obstructive pancreatitis distal to the tumor.
S Kubo; K Yamamoto; Y Magata; Y Iwasaki; N Tamaki; Y Yonekura; J Konishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  5     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-04-16     Completed Date:  1992-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Department of Radiology and Nuclear Medicine, Kyoto University School of Medicine, Japan.
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MeSH Terms
Middle Aged
Oxygen Radioisotopes / diagnostic use
Pancreas / blood supply*,  radionuclide imaging
Pancreatic Neoplasms / blood supply*,  radionuclide imaging
Reference Values
Regional Blood Flow
Tomography, Emission-Computed*
Reg. No./Substance:
0/Oxygen Radioisotopes; 7732-18-5/Water

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