Document Detail

Assessment of osteoporosis in psoriasis with and without arthritis: correlation with disease severity.
MedLine Citation:
PMID:  21182499     Owner:  NLM     Status:  In-Process    
BACKGROUND: The most frequent extracutaneous association with psoriasis is arthritis. Because proinflammatory cytokines are increased in psoriasis, patients with this disease may be more prone to osteoporosis than the healthy individuals.
METHODS: We evaluated 50 patients with psoriasis, with or without psoriatic arthritis (PsA), for the presence and degree of osteoporosis by performing dual energy x-ray absorptiometry (DEXA) and obtaining serum osteoprotegrin (OPG) levels. In addition, we correlated these results with the extent of skin and joint disease. Psoriasis area and severity index (PASI) was determined in all 50 patients with psoriasis, and total joint score (TJS) was recorded in the 16 patients who also had PsA. Results of DEXA and serum OPG were also obtained for 20 healthy individuals who served as controls.
RESULTS: Osteoprotegrin level was significantly increased in psoriasis patients (with or without PsA) vs. controls. However, DEXA revealed that PsA patients had a higher degree of osteoporosis in the femur neck and wrist. In PsA patients, TJS correlated positively with both disease duration and PASI but correlated negatively with Z score of the femur.
CONCLUSION: Psoriasis patients with or without arthritis may suffer from osteoporosis as evidenced by significantly increased serum OPG. Prolonged and extensive cutaneous disease is an important risk factor for the development and severity of PsA. Patients with a greater number of affected joints are at higher risk of osteoporosis.
Enas A S Attia; Ayman Khafagy; Sameh Abdel-Raheem; Sahar Fathi; Abeer A Saad
Related Documents :
11554939 - Early transfusion of factor viii/von willebrand factor concentrates seems to be effecti...
21514549 - Nail psoriasis in individuals with psoriasis vulgaris: a study of 661 patients.
18393149 - The phenotypic heterogeneity of severe hemophilia.
21172929 - Retinal vascular calibre is altered in patients with rheumatoid arthritis: a biomarker ...
21445609 - Pulmonary vascular disease in gaucher disease: clinical spectrum, determinants of pheno...
9527099 - Activation of blood coagulation in patients with mitral stenosis and sinus rhythm.
3895389 - Psychological aspects of non-ulcer dyspepsia: a psychosomatic view focusing on a compar...
1253379 - Second degree block during reciprocal atrioventricular nodal tachycardia.
17050329 - Clinical, andrological and genetic characteristics of patients with congenital bilatera...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  50     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Copyright Information:
© 2011 The International Society of Dermatology.
Departments of Dermatology, Venereology, and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immunohistochemical expression of cyclooxygenage-2 in melanocytic skin lesions.
Next Document:  Prurigo pigmentosa: a clinicopathological study and analysis of associated factors.