Document Detail

Assessment of opiate modulation of pain and nociceptive responding in young adults with a parental history of hypertension.
MedLine Citation:
PMID:  15936866     Owner:  NLM     Status:  MEDLINE    
This double blind, placebo-controlled study examined the effects of an opiate antagonist, naltrexone, on nociceptive flexion reflex (NFR) thresholds and subjective pain in individuals with and without a parental history of hypertension. Using a repeated measures design, NFR threshold was repeatedly assessed on two testing days after administration of either placebo or naltrexone. Immediately after NFR threshold was determined, participants rated the level of pain experienced during the preceding NFR assessment, and at the end of each session participants' electrocutaneous pain threshold was assessed. Two primary findings were obtained. First, individuals with a parental history of hypertension exhibited attenuated pain sensitivity. Second, endogenous opioid blockade was associated with increased pain ratings in women but with increased pain threshold in men. In sum, the present study did not support a direct involvement of the endogenous opioid system in the attenuated pain sensitivity observed in individuals at increased risk for hypertension.
Christopher R France; Mustafa al'absi; Christopher Ring; Janis L France; John Brose; Donald Spaeth; Angie Harju; Glenn Nordehn; Lorentz E Wittmers
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2005-06-03
Journal Detail:
Title:  Biological psychology     Volume:  70     ISSN:  0301-0511     ISO Abbreviation:  Biol Psychol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-10-24     Completed Date:  2006-01-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375566     Medline TA:  Biol Psychol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  168-74     Citation Subset:  IM    
Department of Psychology, Ohio University, 245 Porter Hall, Athens, OH 45701, USA.
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MeSH Terms
Double-Blind Method
Hypertension / complications,  etiology,  genetics*
Naltrexone / pharmacology*
Narcotic Antagonists / pharmacology*
Pain Measurement
Pain Threshold*
Risk Factors
Grant Support
Reg. No./Substance:
0/Narcotic Antagonists; 0/Placebos; 16590-41-3/Naltrexone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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