Document Detail

Assessment of nutritional status: vitamin A and zinc in patients with common variable immunodeficiency.
MedLine Citation:
PMID:  23101187     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with common variable immunodeficiency (CVID) present with low antibody levels, impaired lymphocyte function, and chronic inflammation. Vitamin A and zinc are essential components of the immune system and can be redistributed in the body as a result of inflammation.
OBJECTIVE: To compare levels of retinol, beta-carotene, and zinc in patients with CVID and healthy controls after evaluating a series of parameters for each participant.
PATIENTS AND METHODS: We performed a cross-sectional study of CVID patients and healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising a complete blood count and determination of levels of C-reactive protein (CRP), lipopolysaccharide (LPS), soluble CD14 (sCD14), retinol, beta-carotene, and serum and erythrocyte zinc.
RESULTS: We included 17 patients (mean age, 28.54 years) and 17 controls. Mean (SD) retinol levels were lower in patients: 1.99 (0.67) micromol/L vs 2.72 (0.96) micromol/L. Median beta-carotene levels were similar in both groups (0.30 micromol/L). Median serum zinc levels were 50.0 microg/dL (50-100 microg/dL) in the patients and 100.0 microg/dL (50-150 microg/dL) in the controls. Mean levels of erythrocyte zinc were lower among patients: 37.32 (10.51) microgZn/gHb vs 44.91 (7.67) microgZn/gHb in the controls. Median CRP levels were significantly higher among patients: 4.99 (0.15-34.51) mg/L vs 0.55 (0.17-6.06) mg/L. No differences in translocation marker levels were observed between the groups.
CONCLUSIONS: CVID patients had lower levels of retinol and zinc than controls. Since micronutrient deficiency could aggravate their disease and contribute to chronic inflammation, micronutrient status should always be assessed in patients with primary immunodeficiency.
E Calheiro dos Santos-Valente; R da Silva; M I de Moraes-Pinto; R Oselka Saccardo Sarni; B T Costa-Carvalho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigational allergology & clinical immunology     Volume:  22     ISSN:  1018-9068     ISO Abbreviation:  J Investig Allergol Clin Immunol     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-01-09     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9107858     Medline TA:  J Investig Allergol Clin Immunol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  427-31     Citation Subset:  IM    
Federal University of Sao Paulo, Sao Paulo-SP, Brazil.
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MeSH Terms
Antigens, CD14 / blood
C-Reactive Protein / metabolism
Common Variable Immunodeficiency / diagnosis*,  metabolism
Erythrocytes / metabolism
Nutritional Status / immunology*
Vitamin A / blood*
Young Adult
Zinc / metabolism*
beta Carotene / blood
Reg. No./Substance:
0/Antigens, CD14; 11103-57-4/Vitamin A; 7235-40-7/beta Carotene; 7440-66-6/Zinc; 9007-41-4/C-Reactive Protein

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