Document Detail


Assessment of a novel stentless mitral valve using a pulsatile mitral valve simulator.
MedLine Citation:
PMID:  22474745     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND AND AIM OF THE STUDY: The study aim was to develop a novel stentless mitral valve (SMV) and to evaluate its performance, using an original pulsatile simulator developed specifically to analyze the hydrodynamic function of the mitral valve.
METHODS: The SMV developed at the authors' institution consists of two major components: a large anterior leaflet with commissures, and a small posterior leaflet. The valve is formed by suturing the leaflets (made from bovine pericardium) to a flexible (Duran) ring. The SMV, constructed with a 27 mm flexible ring, was installed into the mitral valve simulator, after which the four papillary flaps of the two leaflets were sutured to artificial papillary muscles. The artificial ventricle was driven pneumatically at a pulse rate of 70 beats/min, with a systolic fraction of 35%. The mean flow, aortic pressure, and atrial pressure were adjusted to 4.5 1/min, 120/80 mmHg, and 10 mmHg, respectively. A 27 mm mechanical valve (MEV; St. Jude Medical Inc.) was employed as a control. The hydrodynamic performance of the SMV and MEV were investigated and compared. An echo-Doppler study was also performed.
RESULTS: The waveforms of the SMV and MEV showed a similar pattern. The mean transvalvular flow was 4.7 +/- 0.4 1/min for the SMV, and 3.55 +/- 0.13 1/min for the MEV (p < 0.001). Mitral regurgitation was 5.07 +/- 1.15 and 3.78 +/- 0.35 ml/beat, respectively (p < 0.05). Echocardiographic data indicated that the regurgitant jet towards the left atrial model was none or trivial for the SMV, and trivial for the MEV.
CONCLUSION: Within the environment of the mitral valve simulator, the novel SMV prepared from bovine pericardium demonstrated excellent performance characteristics, and may represent a potential future alternative for bioprosthetic stented mitral valves.
Authors:
Hitoshi Kasegawa; Kiyotaka Iwasaki; Shyunsuke Kusunose; Ryota Tatusta; Tetsuya Doi; Hiroki Yasuda; Mitsuo Umezu
Related Documents :
23813065 - Angiographic evaluation of the radial artery diameter in patients who underwent coronar...
22976945 - A successful septal ablation of the first septal perforator artery arising from the cir...
24256965 - Intracranial aneurysms and vascular malformations: diagnosis and therapy. a long-term s...
23108515 - Doppler echocardiographic indices in aortic coarctation: a comparison of profiles befor...
7146885 - Subacute pulmonary hypertension and systemic tumour embolism from cervical cancer.
18095215 - Sildenafil use in a symptomatic neonate with severe ebstein's anomaly of the tricuspid ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  21     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Affiliation:
Center for Advanced Biomedical Sciences, Waseda University, Tokyo, Japan. zbn25716@nifty.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early surgery for asymptomatic mitral regurgitation: importance of atrial fibrillation.
Next Document:  Patterns of anticoagulation following bioprosthetic valve implantation: observations from ANSWER.