Document Detail


Assessment of a new modified soft jelly capsule containing nonoxynol as spermicide contraceptive.
MedLine Citation:
PMID:  1317089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mean rupture time, after its vaginal insertion, of a new modified soft jelly capsule containing nonoxynol-9 (DF-486) was investigated in 40 women. The subjects were randomly allocated to 8 study groups. The capsules remained in the vagina from 2-13 minutes. Vaginal infection, vaginal dryness, and multiparity, were recorded. Capsule rupture was not observed at minute 2; 20% of capsules that remained in the vagina 3 minutes suffered rupture, as did 80% of capsules that remained 4, 5 and 7 minutes, and 100% of those remaining 9 minutes or more. The mean rupture time of the studied capsules was 8.2 minutes with 95% confidence limits of 6.2 and 8.8 minutes. At minutes 2-7, vaginal infection, dryness and tone diminution probably accounted for lack of rupture; after minute 7, these factors did not influence capsule rupture.
Authors:
R Recio; S Bassol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in contraception : the official journal of the Society for the Advancement of Contraception     Volume:  8     ISSN:  0267-4874     ISO Abbreviation:  Adv Contracept     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-19     Completed Date:  1992-06-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8607435     Medline TA:  Adv Contracept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
Affiliation:
Department of Reproductive Biology, University of Coahuila, School of Medicine, Torreon, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intravaginal
Adult
Capsules
Evaluation Studies as Topic
Female
Humans
Nonoxynol
Polyethylene Glycols / administration & dosage*,  adverse effects
Spermatocidal Agents / administration & dosage*,  adverse effects
Time Factors
Chemical
Reg. No./Substance:
0/Capsules; 0/Polyethylene Glycols; 0/Spermatocidal Agents; 26027-38-3/Nonoxynol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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