| Assessment of a new mathematical model for the computation of numerical parameters related to renal cortical blood flow and fractional blood volume by contrast-enhanced ultrasound. | |
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MedLine Citation:
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PMID: 19193486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analyzed the value of a new mathematical model for the quantification of renal cortical blood flow and fractional blood volume by contrast-enhanced ultrasound after the injection of sulfur hexafluoride-filled microbubbles. A vessel-mimicking phantom experiment was preliminarily performed which showed that the effect of microbubble diffusion is negligible compared with the effect of liquid drag. Twelve healthy volunteers (7 male, 5 female; 27 to 48 years [n = 6; group 1], and 61 to 80 years [n = 6; group 2], respectively), with normal renal and cardiac function and not undergoing any pharmacologic treatment, were examined. In each volunteer, both kidneys were scanned after intravenous injection of sulfur hexafluoride-filled microbubbles at a slow rate (4.8 mL at a flow of 4.0 mL/min), and the refill kinetics of the renal cortex after microbubble destruction was evaluated by echo-signal intensity quantification. The progressive replenishment of the renal vessels was approximated both by standard negative exponential function and by the piecewise linear function resulting from our mathematical model. A better dataset approximation was provided by piecewise linear versus standard negative exponential function (overall mean square error: 0.44 vs. 0.51; p < 0.05, Wilcoxon test). The piecewise linear function provided a curve composed of four linear tracts (n = 3 volunteers; 2 from group 1 and 1 from group 2), three linear tracts (n = 6 volunteers; 3 from group 1 and 3 from group 2) or two linear tracts (n = 3 volunteers; 1 from group 1 and 2 from group 2). The piecewise linear function versus standard negative exponential function improved data approximation for the computation of numerical values related to renal cortical blood flow velocity and fractional blood volume. |
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Authors:
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Emilio Quaia; Aldo Nocentini; Lucio Torelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-04 |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 35 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 616-27 Citation Subset: IM |
Affiliation:
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Department of Radiology, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy. quaia@univ.trieste.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Blood Volume Contrast Media / administration & dosage Female Humans Kidney Cortex / blood supply*, ultrasonography* Linear Models Male Microbubbles Middle Aged Models, Biological* Phantoms, Imaging Renal Circulation Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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