Document Detail

Assessment of myoelectrical signal parameters in estrogen, progesterone, and human chorionic gonadotropin administered in nonpregnant rat myometrium after ovariectomy.
MedLine Citation:
PMID:  17509589     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the correlation of myoelectrical signals with spontaneous contractile events and physiological states in the nonisolated uterine horn of rats. DESIGN: In vivo uterine myoelectrical activity recording study. SETTING: Animal and pharmacology laboratory at Inonu University. ANIMAL(S): Thirty-six female Wistar albino rats. INTERVENTION(S): Six animals were not castrated and served as a sham-operated control group; the other 30 were ovariectomized (OVX) and put into groups: unbiased OVX subjects, estrogen (E)-biased OVX subjects, P-biased OVX subjects, E-plus-P-biased OVX subjects, and hCG-biased OVX subjects. An MP100 A-CE was used for data acquisition, and a personal computer was used for processing. MAIN OUTCOME MEASURE(S): Besides the temporal, spectral, and joint time-frequency (spectrotemporal) analysis, some quantitative measures such as standard deviation and mark to space power ratios of myoelectrical signals were measured. RESULT(S): Progesterone, E, and hCG administration down-regulated the power and contraction frequency of the uterine electrical signal. The spectral concentrations that occurred around the 0.9, 0.35, and 0.7 Hz frequency ranges may be distinguishing characteristics for P, E, and hCG, respectively. CONCLUSION(S): Based on the obtained results, uterine contractions change with ovariectomy and administration of hormones. Progesterone, E, and hCG particularly prolong the quiescent periods of the uterus by reducing the frequency of uterine contractions as well as the power of the myoelectrical activity. Individual or combined use of P, E, or hCG might favor quiescence of the uterine muscle and the maintenance of pregnancy.
Onder Celik; Seyma Hascalik; M Emin Tagluk; Koray Elter; Hakan Parlakpinar; Ahmet Acet
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Publication Detail:
Type:  Journal Article     Date:  2007-05-16
Journal Detail:
Title:  Fertility and sterility     Volume:  89     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-98     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Inonu University Medical Faculty, Malatya, Turkey.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage*
Estrogens, Conjugated (USP) / administration & dosage*
Fertility Agents, Female / administration & dosage*
Membrane Potentials / drug effects
Myometrium / drug effects*
Progesterone / administration & dosage*
Rats, Wistar
Signal Processing, Computer-Assisted
Time Factors
Uterine Contraction / drug effects*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Estrogens, Conjugated (USP); 0/Fertility Agents, Female; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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