Document Detail

Assessment of myocardial viability in a porcine model of chronic coronary artery stenosis with dual dose dobutamine magnetic resonance imaging.
MedLine Citation:
PMID:  12602484     Owner:  NLM     Status:  MEDLINE    
In a non-surgical porcine coronary stenosis model resulting in chronic left ventricle dysfunction, we aimed in this study to evaluate the potential of magnetic resonance imaging (MRI) to distinguish dysfunctional but viable from necrotic myocardium by using multiple levels of dobutamine inotropic stimulation during a cine MRI protocol (F.P. van Rugge et al. Circulation 1994; 90: 127-138). We compared our results with histopathology. We were able to demonstrate a biphasic effect at increasing doses of dobutamine in a subgroup of animals with a high-grade coronary stenosis, while in another subgroup the coronary stenosis produced a chronic myocardial infarction, in which no functional recovery could be obtained. In this experimental protocol, dual dose dobutamine MRI proved to be an accurate and reproducible technique to perform viability studies in chronic obstructive coronary artery disease. It permits distinguishing chronic ischemic, but viable myocardium from infarcted tissue. The detection of chronically underperfused but potentially salvageable myocardium is of significant clinical importance since it may aid in determining which patients are eligible for revascularization.
S Dymarkowski; M Szilard; A Maes; X S Liu; Y M Huang; E Verbeken; L Mortelmans; J Bogaert; I De Scheerder
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  19     ISSN:  1569-5794     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
Department of Radiology, MR Research Center, University Hospital Gasthuisberg, Belgium.
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MeSH Terms
Cell Survival
Coronary Stenosis / diagnosis*
Disease Models, Animal
Dobutamine / diagnostic use
Magnetic Resonance Imaging*
Myocardium / pathology*
Observer Variation
Severity of Illness Index
Sympathomimetics / diagnostic use
Ventricular Dysfunction, Left / diagnosis*
Ventricular Function, Left / physiology
Reg. No./Substance:
0/Sympathomimetics; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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