Document Detail

Assessment of myocardial viability by radionuclide and echocardiographic techniques: is it simply a sensitivity and specificity issue?
MedLine Citation:
PMID:  16900007     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The assessment of myocardial viability provides important information that may guide therapeutic decisions in patients with coronary artery disease and left ventricular dysfunction. This review describes methods for assessing myocardial viability using single-photon emission computed tomography, with an emphasis on how to optimize the detection of viable myocardium using current techniques. Relevant comparisons of radionuclide techniques with echocardiographic methods are also discussed. RECENT FINDINGS: The basis for the assessment of myocardial viability using radionuclides is reviewed briefly. Radionuclide techniques provide important prognostic information that may affect the decision on if patients with coronary artery disease should be revascularized or treated medically. Data suggest that dobutamine stress echocardiography may underestimate viability in certain patients. Radionuclide techniques that assess both radiotracer uptake and ventricular function can provide a comprehensive approach to detect viable myocardium in most patients. SUMMARY: The methods for assessing myocardial viability using single-photon emission computed tomography are accurate, reproducible, and widely available. Viability testing should be considered in patients with known coronary artery disease and left ventricular dysfunction. Further studies are warranted to assess the affect of viability assessment on clinical outcomes.
James A Arrighi; Vasken Dilsizian
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in cardiology     Volume:  21     ISSN:  0268-4705     ISO Abbreviation:  Curr. Opin. Cardiol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-12-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8608087     Medline TA:  Curr Opin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  450-6     Citation Subset:  IM    
Department of Medicine and Diagnostic Imaging, Brown Medical School, Providence, Rhode Island, USA.
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MeSH Terms
Coronary Artery Disease / diagnosis,  physiopathology,  radionuclide imaging
Echocardiography / methods*
Heart / physiopathology*,  radionuclide imaging
Myocardial Contraction / physiology
Sensitivity and Specificity
Tissue Survival / physiology*
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / diagnosis,  physiopathology,  radionuclide imaging

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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