Document Detail

Assessment of myocardial response to pharmacologic interventions using an improved MR imaging technique to estimate T2 values.
MedLine Citation:
PMID:  9888756     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our objective was to improve a previously developed MR imaging sequence for the in vivo estimation of the myocardial T2* value and to evaluate, in healthy human subjects, the response of myocardial T2* value to two different pharmacologic interventions.
CONCLUSION: The modified technique improved the quality of the images obtained and increased the reliability of myocardial T2* measurements. Using the modified technique, the myocardial T2* value increased significantly over baseline values after the administration of dipyridamole but did not significantly change after the administration of dobutamine. These observations are consistent with the expected response of myocardial venous blood oxygen saturation levels to the infusion of the two pharmacologic agents.
D Li; W F Oellerich; G Beck; R J Gropler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  172     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-03-17     Completed Date:  1999-03-17     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  AIM; IM    
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Blood Pressure / drug effects
Coronary Circulation / drug effects
Dipyridamole / pharmacology*
Dobutamine / pharmacology*
Heart / anatomy & histology*
Heart Rate / drug effects
Magnetic Resonance Imaging / methods*
Oxygen / blood
Grant Support
Reg. No./Substance:
34368-04-2/Dobutamine; 58-32-2/Dipyridamole; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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