| Assessment of myocardial ischemic memory using persistence of post-systolic thickening after recovery from ischemia. | |
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MedLine Citation:
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PMID: 19909928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to investigate the time course of post-systolic thickening (PST) and systolic abnormality after recovery from brief myocardial ischemia. BACKGROUND: Myocardial ischemic memory imaging, denoting the visualization of abnormalities provoked by ischemia and sustained even after restoration of perfusion, is desirable and allows after-the-fact recognition of ischemic insult. PST offers a sensitive marker of myocardial ischemia, but whether this abnormal thickening remains after relief from brief ischemia is unclear. METHODS: Tissue strain echocardiographic data were acquired from 27 dogs under 2 different conditions of myocardial ischemia induced by either brief coronary occlusion (15 or 5 min) followed by reperfusion (Protocol 1) or by dobutamine stress during nonflow-limiting stenosis (Protocol 2). Peak systolic strain and post-systolic strain index (PSI), a parameter of PST, were analyzed. RESULTS: In Protocol 1, peak systolic strain was significantly decreased in the risk area during occlusion. This decrease in peak systolic strain in the 15-min group did not completely recover to baseline levels even 120 min after reperfusion, whereas the decrease in the 5-min group recovered immediately after reperfusion. We found that PSI was significantly increased during occlusion, but increased PSI in the 5-min group remained until 30 min after reperfusion (-0.19 +/- 0.18 [baseline] vs. 0.19 +/- 0.14 [30 min], p < 0.05) despite the rapid recovery of peak systolic strain. In Protocol 2, increased PSI was sustained until 20 min after the end of dobutamine infusion (-0.26 +/- 0.11 [baseline] vs. -0.16 +/- 0.10 [20 min], p < 0.05), although peak systolic strain recovered by 5 min after the end of dobutamine infusion. CONCLUSIONS: PST remained longer than abnormal peak systolic strain after recovery from ischemia. Assessment of PST may be valuable for detecting myocardial ischemic memory. |
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Authors:
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Toshihiko Asanuma; Ayumi Uranishi; Kasumi Masuda; Fuminobu Ishikura; Shintaro Beppu; Satoshi Nakatani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: JACC. Cardiovascular imaging Volume: 2 ISSN: 1876-7591 ISO Abbreviation: JACC Cardiovasc Imaging Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101467978 Medline TA: JACC Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1253-61 Citation Subset: IM |
Affiliation:
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Department of Functional Diagnostic Science, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. toshi@sahs.med.osaka-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Disease Models, Animal Dogs Echocardiography, Doppler, Color Heart Rate Myocardial Contraction* Myocardial Ischemia / physiopathology*, ultrasonography Myocardium / pathology Necrosis Observer Variation Recovery of Function Reproducibility of Results Systole Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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