Document Detail

Assessment of myocardial damage by circulating cardiac myosin light chain I after heart transplantation.
MedLine Citation:
PMID:  8061017     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the cardiac damage by cardiac myosin light chain I after transplantation. This study included 30 patients who underwent cardiac operations and who were divided into three groups. These groups consisted of (1) control group, 15 valvular patients without coronary disease (no electrocardiography changes and creatine kinase MB isoenzyme of 100 micrograms/L or less); (2) infarction group, eight patients (six coronary bypass and two valvular patients with perioperative infarction pattern in the electrocardiography and creatine kinase MB isoenzyme of 100 micrograms/L or more; and (3) transplantation group, seven transplant patients (six heart and one heart-lung). The peak cardiac myosin light chain I value in the transplantation group (32.9 +/- 3.4 micrograms/L) was comparable to the infarction group (27.6 +/- 2.6 micrograms/L), and both of them were significantly higher than the control group (9.2 +/- 0.9 micrograms/L) (p < 0.01). Peak cardiac myosin light chain I levels in the control and transplantation groups correlated with the ischemic time (r = 0.48, p < 0.05 and r = 0.67, p < 0.05, respectively). The total dose of dopamine in the transplantation group correlated with the peak cardiac myosin light chain I (r = 0.67, p < 0.05), and with the cardiac myosin light chain I value on day 7 (r = 0.88, p < 0.01). This study suggests that circulating cardiac myosin light chain I estimations are useful to evaluate myocardial damage after transplantation during postoperative week 1.
T Uchino; A Belboul; A el-Gatit; D Roberts; E Berglin; G William-Olsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  13     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1994-09-19     Completed Date:  1994-09-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  418-23     Citation Subset:  IM    
Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Hospital, University of Gothenburg, Sweden.
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MeSH Terms
Biological Markers / blood
Cardioplegic Solutions
Cardiopulmonary Bypass
Cold Temperature
Coronary Artery Bypass
Creatine Kinase / blood
Dopamine / therapeutic use
Heart Transplantation* / pathology,  physiology
Heart Valves / surgery
Hypothermia, Induced
Middle Aged
Myocardial Infarction / blood,  physiopathology
Myocardial Ischemia / blood*,  physiopathology
Myocardium / metabolism*
Myosin Light Chains*
Myosins / blood*,  metabolism
Organ Preservation
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Cardioplegic Solutions; 0/Isoenzymes; 0/Myosin Light Chains; 0/myosin light chain I; EC Kinase; EC

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