| Assessment of the multi-mycotoxin-binding efficacy of a carbon/aluminosilicate-based product in an in vitro gastrointestinal model. | |
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MedLine Citation:
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PMID: 17511466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A laboratory model, set to simulate the in vivo conditions of the porcine gastrointestinal tract, was used to study the small intestinal absorption of several mycotoxins and the effectiveness of Standard Q/FIS (a carbon/aluminosilicate-based product) in reducing mycotoxin absorption when added to multitoxin-contaminated diets. Mycotoxins were quickly absorbed in the proximal part of the small intestine at levels of 105 and 89% for fumonisins B1 and B2, respectively, 87% for ochratoxin A, 74% for deoxynivalenol, 44% for aflatoxin B1, and 25% for zearalenone. Addition of Standard Q/FIS to the diet (up to 2%, w/w) significantly reduced mycotoxin absorption, in a dose-dependent manner, up to 88% for aflatoxin B1, 44% for zearalenone, and 29% for the fumonisins and ochratoxin. Standard Q/FIS was ineffective in reducing deoxynivalenol uptake. These findings suggest that Standard Q/FIS can be used as a multitoxin adsorbent material to prevent the individual and combined adverse effects of mycotoxins in animals. |
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Authors:
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Giuseppina Avantaggiato; Robert Havenaar; Angelo Visconti |
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Publication Detail:
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Type: Journal Article Date: 2007-05-19 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 55 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-06 Completed Date: 2007-09-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 4810-9 Citation Subset: IM |
Affiliation:
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CNR Institute of Sciences of Food Production (ISPA), Via Amendola122/O, I-70126 Bari, Italy. giuseppina.avantaggiato@ispa.cnr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Aluminum Silicates Animal Feed Animals Binding Sites Carbon Gastric Emptying / physiology* Gastrointestinal Tract / physiology* Gastrointestinal Transit Hydrogen-Ion Concentration Models, Biological Mycotoxins / analysis*, metabolism Swine |
| Chemical | |
Reg. No./Substance:
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0/Aluminum Silicates; 0/Mycotoxins; 1327-36-2/aluminosilicate; 7440-44-0/Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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