| Assessment of mitochondrial function and control in normal and diseased states. | |
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MedLine Citation:
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PMID: 7599201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitochondrial function in muscle in vivo can be quantitatively evaluated using 31-phosphorus nuclear magnetic resonance. In resting muscle, the concentrations of ions (e.g. H+, Na+) and two of the major bioenergetic components (inorganic phosphate and creatine) are determined by regulated transcellular transport processes. During recovery after exercise the kinetics and control of mitochondrial ATP synthesis can be established. During exercise the relative contributions to ATP synthesis of phosphocreatine (using creatine kinase), anaerobic glycogenolysis and oxidative phosphorylation are dissected and have been shown to change with time. The consequences of mitochondrial lesions and dysfunctions on these processes have been summarised. |
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Authors:
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G K Radda; J Odoom; G Kemp; D J Taylor; C Thompson; P Styles |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1271 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-08-07 Completed Date: 1995-08-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 15-9 Citation Subset: IM |
Affiliation:
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MRC Biochemical and Clinical Magnetic Resonance Unit, Oxford Radcliffe Hospital, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Energy Metabolism Humans Ischemia / metabolism Kinetics Magnetic Resonance Spectroscopy / diagnostic use Mitochondria / metabolism* Mitochondrial Myopathies / diagnosis, metabolism* Phosphocreatine / metabolism Reference Values Renal Dialysis Uremia / metabolism, therapy |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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