Document Detail


Assessment of mitochondrial function and control in normal and diseased states.
MedLine Citation:
PMID:  7599201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitochondrial function in muscle in vivo can be quantitatively evaluated using 31-phosphorus nuclear magnetic resonance. In resting muscle, the concentrations of ions (e.g. H+, Na+) and two of the major bioenergetic components (inorganic phosphate and creatine) are determined by regulated transcellular transport processes. During recovery after exercise the kinetics and control of mitochondrial ATP synthesis can be established. During exercise the relative contributions to ATP synthesis of phosphocreatine (using creatine kinase), anaerobic glycogenolysis and oxidative phosphorylation are dissected and have been shown to change with time. The consequences of mitochondrial lesions and dysfunctions on these processes have been summarised.
Authors:
G K Radda; J Odoom; G Kemp; D J Taylor; C Thompson; P Styles
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1271     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-07     Completed Date:  1995-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Affiliation:
MRC Biochemical and Clinical Magnetic Resonance Unit, Oxford Radcliffe Hospital, UK.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Energy Metabolism
Humans
Ischemia / metabolism
Kinetics
Magnetic Resonance Spectroscopy / diagnostic use
Mitochondria / metabolism*
Mitochondrial Myopathies / diagnosis,  metabolism*
Phosphocreatine / metabolism
Reference Values
Renal Dialysis
Uremia / metabolism,  therapy
Chemical
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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