Document Detail

Assessment of minimal residual disease in acute promyelocytic leukaemia with t(15;17) by chromosome painting.
MedLine Citation:
PMID:  7615044     Owner:  NLM     Status:  MEDLINE    
To detect the minimal residual disease (MRD) in acute promyelocytic leukaemia patients treated with all-trans retinoic acid, we compared the sensitivity of metaphase fluorescence in situ hybridization (FISH) with conventional analysis of G-banded metaphases. 5 out of 6 patients studied at diagnosis showed the t(15;17) translocation. 4 out of 5 patients carrying t(15;17) achieved complete remission and conventional cytogenetic conversion. In 3 cases the whole chromosome painting (WCP) probe 17 discovered one normal chromosome 17 and two fragments indicative of t(15;17) persistence. The FISH-WCP technique seems to be highly sensitive and recommendable in monitoring leukaemias with specific chromosome rearrangements.
P Temperani; P Vaccari; F Giacobbi; G Gandini; M G Ferrari; G Emilia
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of haematology     Volume:  55     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-24     Completed Date:  1995-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  10-3     Citation Subset:  IM    
Department of Medical Sciences, University of Modena, Italy.
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MeSH Terms
Chromosome Banding
Chromosomes, Human, Pair 17 / genetics
In Situ Hybridization
Leukemia, Promyelocytic, Acute / diagnosis*,  drug therapy,  genetics
Middle Aged
Neoplasm, Residual
Translocation, Genetic
Tretinoin / therapeutic use
Reg. No./Substance:

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