| Assessment of microvascular changes in Raynaud's phenomenon and connective tissue disease using colour doppler ultrasound. | |
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MedLine Citation:
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PMID: 11085798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We used colour Doppler ultrasound (CDU) to differentiate primary from secondary Raynaud's phenomenon (pRP and sRP, respectively) and to assess digital vascular damage in patients with connective tissue disease (CTD). METHODS: Vascularity in the nailbeds of 15 healthy controls and 35 patients with CTD (systemic sclerosis or systemic lupus erythematosus) was quantified using a multi-D array transducer before and after cold and warm challenge, respectively. The results were compared with the clinically evaluated initial skin lesions. Vascularity was compared similarly between 10 pRP and 22 sRP patients. RESULTS: Vascularity at ambient temperature differed between healthy subjects and sRP patients as well as between healthy subjects and CTD patients without initial skin lesions. Patients with pRP had normal vascularity at ambient temperature but differed from healthy controls in response to a dynamic temperature challenge. CDU confirmed the clinical evaluation in 89.4% of the patients with RP and in 78.0% of the skin lesions. CONCLUSION: The novel CDU technique presented here makes it possible to discriminate between pRP and sRP and to quantify vascular changes in CTD patients. |
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Authors:
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M Keberle; H P Tony; R Jahns; M Hau; R Haerten; M Jenett |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 39 ISSN: 1462-0324 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-12-08 Completed Date: 2000-12-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1206-13 Citation Subset: AIM; IM |
Affiliation:
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Institut für Röntgendiagnostik, University of Würzburg, Würzburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cold Temperature / diagnostic use Diagnosis, Differential Female Fingers / blood supply Hot Temperature / diagnostic use Humans Lupus Erythematosus, Systemic / complications, pathology, ultrasonography* Male Microcirculation Middle Aged Radial Artery Raynaud Disease / etiology, pathology, ultrasonography* Regional Blood Flow Scleroderma, Systemic / complications, pathology, ultrasonography* Ulnar Artery Ultrasonography, Doppler, Color* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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