| Assessment of the microRNA system in salt-sensitive hypertension. | |
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MedLine Citation:
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PMID: 16471176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most animal microRNAs are imperfectly complementary to their mRNA targets and inhibit protein synthesis through an unknown mechanism. MicroRNAs have been reported to play important roles in a number of biological processes. We assessed the microRNA system in Dahl salt-sensitive rats in order to investigate possible roles of microRNA in salt-sensitive hypertension. We constructed microRNA libraries from the kidneys of Dahl salt-sensitive and Lewis rats taking normal or high-salt diets (4 groups), and identified 91 previously reported and 12 new microRNAs expressed in the kidney. We then used Northern blotting to assess the expression levels of 118 microRNAs in the kidneys and heart ventricles. No significant differences in microRNA expression profiles were observed among the 4 groups. Thus, the microRNA system seemed to be unlikely to contribute to salt-sensitive hypertension in Dahl salt-sensitive rats. |
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Authors:
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Hiroaki Naraba; Naoharu Iwai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 28 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2006-02-13 Completed Date: 2006-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 819-26 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Profiling Hypertension / metabolism* Kidney / metabolism MicroRNAs / analysis* Rats Rats, Inbred Dahl Rats, Inbred Lew |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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