Document Detail

Assessment of manidipine on left ventricular function in Chinese hypertensive patients using a tissue Doppler imaging (TDI) Tei index.
MedLine Citation:
PMID:  21111566     Owner:  NLM     Status:  Publisher    
Despite normal indices of left ventricular (LV) chamber function, impaired diastolic and systolic function are thought to coexist in hypertensive patients. The aim of this study was to investigate the effects of short-term manidipine therapy on LV global function in Chinese patients with hypertension using the tissue Doppler imaging (TDI) Tei index. Forty-eight patients with mild to moderate essential hypertension underwent a 2-week placebo run-in period, then received 10 to 20mg/day of manidipine orally for 8 weeks. At the end of the placebo period and treatment, patients were examined by echocardiography. Twenty-five healthy patients were recruited and also underwent an echocardiography study. The mitral annular motions at the lateral, septum, inferior, and anterior sides were recorded. The TDI Tei index was calculated as a diastolic time interval measured from the end of a late diastole to the origin of an early diastole (a) minus systolic peak velocities duration (b) divided by b, which is the Tei index: (a-b)/b. The Tei index was significantly higher in the hypertensive group. After treatment, the Tei index was significantly lower without obvious changes in the transmitral inflow velocity. Moreover, changes in the Tei index showed no correlation with changes in blood pressure.
Yuan-Yuan Wang; Zhi-Yong Ma; Xiao-Hong Kan; Fang-Fang Liu; Li Li; Yun Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-5
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie     Volume:  -     ISSN:  1950-6007     ISO Abbreviation:  -     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology, QiLu Hospital, Shandong University, West Wenhua Road 107, Jinan 250012, China.
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