Document Detail

Assessment and management of high-risk pregnancies in women with thrombophilia.
MedLine Citation:
PMID:  19135285     Owner:  NLM     Status:  MEDLINE    
Pregnancy is an acquired hypercoagulable state which can lead to gestational vascular complications especially in the presence of other prothrombotic risk factors. The use of anticoagulation for prevention of pregnancy complications in women with thrombophilia is becoming more frequent. Efficacy and safety issues of therapeutic and prophylactic regimens use and monitoring of LMWH therapy in pregnancy are discussed in this review. In addition, a scoring system for women with thrombophilia is proposed which includes severity of pregnancy outcomes, thrombotic history and type of thrombophilia. Validation of this scoring system has revealed a significant correlation between the proposed score and LMWH dosages that were prescribed to the studied pregnant women. Careful diagnosis, observation and monitoring can add significant benefit to LMWH therapy during pregnancy.
Galit Sarig; Guy Vidergor; Benjamin Brenner
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-01-08
Journal Detail:
Title:  Blood reviews     Volume:  23     ISSN:  1532-1681     ISO Abbreviation:  Blood Rev.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708558     Medline TA:  Blood Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
Thrombosis and Hemostasis Unit, Rambam Health Care Campus, and the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.
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MeSH Terms
Anticoagulants / administration & dosage,  therapeutic use*
Heparin, Low-Molecular-Weight / administration & dosage,  therapeutic use
Monitoring, Physiologic
Pregnancy Complications, Hematologic / diagnosis*,  drug therapy*
Pregnancy, High-Risk / blood*
Research Design
Thrombophilia / diagnosis*,  drug therapy*
Thrombosis / drug therapy,  prevention & control
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight

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