Document Detail

Assessment of mammographic density before and after first full-term pregnancy.
MedLine Citation:
PMID:  20700056     Owner:  NLM     Status:  MEDLINE    
Mammographic density (MD) has consistently been found as one of the strongest breast cancer risk factors. In our study, both qualitative and quantitative density measurements were performed in a hospital-based group of premenopausal women before and after first full-term pregnancy providing an opportunity for direct evaluation of the effects of one pregnancy on MD. Mammograms were obtained from 23 women before and after first full-term pregnancy and from 28 nulliparous controls. MD was determined by a standard qualitative assessment method using the Breast Imaging Reporting and Data System, and a quantitative computer-based threshold method (0-100%). The mean age at mammography before and after pregnancy was 31 and 34 years, respectively, with a mean difference of 40 months between mammographies. The quantitative density assessment showed a significant reduction in relative MD after pregnancy of 12 percentage points (8.6-15.4), compared with 3.1 (0.0-6.2) in the nulliparous control group (P<0.001). A reduction in MD of more than 10% was seen in 52% of the patients, compared with 18% of the controls. The qualitative density assessment confirmed a reduction in MD after pregnancy by one Breast Imaging Reporting and Data System category (P=0.02). This longitudinal study showed that MD can be influenced by one full-term pregnancy. This effect was seen with both quantitative and qualitative assessment methods. It may be hypothesized that breast cancer risk reduction associated with pregnancy is mediated through a direct reduction of MD, and MD assessment might be incorporated in individualizing risk assessment and prevention.
Christian R Loehberg; Katharina Heusinger; Sebastian M Jud; Lothar Haeberle; Alexander Hein; Claudia Rauh; Mayada R Bani; Michael P Lux; Michael G Schrauder; Christian M Bayer; Cosima Helbig; Ronald Grolik; Boris Adamietz; Ruediger Schulz-Wendtland; Matthias W Beckmann; Peter A Fasching
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)     Volume:  19     ISSN:  1473-5709     ISO Abbreviation:  Eur. J. Cancer Prev.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300837     Medline TA:  Eur J Cancer Prev     Country:  England    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Breast Center Franconia, Erlangen, Germany.
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MeSH Terms
Breast / anatomy & histology*
Longitudinal Studies
Pregnancy / physiology*
Risk Factors
Term Birth*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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