| Assessment of mammographic density before and after first full-term pregnancy. | |
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MedLine Citation:
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PMID: 20700056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mammographic density (MD) has consistently been found as one of the strongest breast cancer risk factors. In our study, both qualitative and quantitative density measurements were performed in a hospital-based group of premenopausal women before and after first full-term pregnancy providing an opportunity for direct evaluation of the effects of one pregnancy on MD. Mammograms were obtained from 23 women before and after first full-term pregnancy and from 28 nulliparous controls. MD was determined by a standard qualitative assessment method using the Breast Imaging Reporting and Data System, and a quantitative computer-based threshold method (0-100%). The mean age at mammography before and after pregnancy was 31 and 34 years, respectively, with a mean difference of 40 months between mammographies. The quantitative density assessment showed a significant reduction in relative MD after pregnancy of 12 percentage points (8.6-15.4), compared with 3.1 (0.0-6.2) in the nulliparous control group (P<0.001). A reduction in MD of more than 10% was seen in 52% of the patients, compared with 18% of the controls. The qualitative density assessment confirmed a reduction in MD after pregnancy by one Breast Imaging Reporting and Data System category (P=0.02). This longitudinal study showed that MD can be influenced by one full-term pregnancy. This effect was seen with both quantitative and qualitative assessment methods. It may be hypothesized that breast cancer risk reduction associated with pregnancy is mediated through a direct reduction of MD, and MD assessment might be incorporated in individualizing risk assessment and prevention. |
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Authors:
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Christian R Loehberg; Katharina Heusinger; Sebastian M Jud; Lothar Haeberle; Alexander Hein; Claudia Rauh; Mayada R Bani; Michael P Lux; Michael G Schrauder; Christian M Bayer; Cosima Helbig; Ronald Grolik; Boris Adamietz; Ruediger Schulz-Wendtland; Matthias W Beckmann; Peter A Fasching |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) Volume: 19 ISSN: 1473-5709 ISO Abbreviation: Eur. J. Cancer Prev. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9300837 Medline TA: Eur J Cancer Prev Country: England |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University Breast Center Franconia, Erlangen, Germany. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breast / anatomy & histology* Female Humans Longitudinal Studies Mammography* Parity* Pregnancy / physiology* Risk Factors Term Birth* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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