Document Detail

Assessment of the longitudinal changes in bone mineral density in patients receiving home parenteral nutrition.
MedLine Citation:
PMID:  15449566     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low bone mineral density (BMD) is commonly reported in patients receiving home parenteral nutrition (HPN), but it remains unclear whether or not an accelerated bone loss occurs during HPN therapy. We evaluated the spinal, hip, and forearm bone mass density longitudinally in a cohort of 75 patients receiving HPN. METHODS: A total of 943 regional dual-energy x-ray absorptiometry scans, 335 spinal, 318 hip, and 290 forearm, obtained between 1995 and 2003 in 75 patients receiving HPN, were used for the analysis of the annual changes in BMD. The average (SD) number of scans per patients was 4.4 (2.9), and follow-up time was 4.1 (1.9) years. Diagnoses were Crohn's disease (n = 35) and other conditions (non-Crohn's diseases; n = 40). Data were analyzed using a linear random coefficient model. RESULTS: There was a statistically significant overall decline over time in spinal, hip, and forearm BMD, corresponding roughly to a 1% annual loss (p < .005); however, the loss was not significantly larger than that of age and sex-matched healthy subjects. In Crohn's disease patients, model estimates of spinal and hip BMD on the initiation of HPN therapy were significantly reduced compared with normal, whereas values were not significantly reduced in non-Crohn's disease patients. CONCLUSIONS: With the current protocols for HPN treatment, the annual decline in BMD is moderate and not significantly larger than in age- and sex-matched healthy subjects. A considerable part of the metabolic bone disease in these patients is related to the underlying disease for which the HPN was indicated.
Kent Valentin Haderslev; Lone Tjellesen; Pernille Heldager Haderslev; Michael Staun
Related Documents :
14554076 - Evaluation of oral and systemic manifestations in an amelogenesis imperfecta population.
15449566 - Assessment of the longitudinal changes in bone mineral density in patients receiving ho...
696426 - Bone mineral loss during maintenance hemodialysis.
23732466 - Cyp3a4-catalyzed simvastatin metabolism as a non-invasive marker of small intestinal he...
2563516 - Misuse of verapamil in pre-excited atrial fibrillation.
620916 - Safety of cimetidine.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  28     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    2004 Sep-Oct
Date Detail:
Created Date:  2004-09-28     Completed Date:  2005-04-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Department of Medical Gastroenterology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Absorptiometry, Photon / methods
Bone Density*
Bone Diseases, Metabolic / epidemiology,  etiology*
Cohort Studies
Crohn Disease / therapy
Forearm / radiography
Hip / radiography
Longitudinal Studies
Middle Aged
Osteoporosis / epidemiology,  etiology*
Parenteral Nutrition, Home / adverse effects*
Spine / radiography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Einthoven: the man and his invention
Next Document:  Early enteral feedings in adults receiving venovenous extracorporeal membrane oxygenation.