| Assessment of lobar perfusion in smokers according to the presence and severity of emphysema: preliminary experience with dual-energy CT angiography. | |
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MedLine Citation:
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PMID: 19533149 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The purpose of the study was to assess pulmonary perfusion on a lobar level in smokers using dual-energy computed tomography (CT). Forty-seven smokers and ten non-smokers underwent a dual-energy multi-detector CT angiogram of the chest that allowed automatic quantification of emphysema and determination of the iodine content at the level of the microcirculation (i.e. "perfusion imaging"). Emphysema was present in 37 smokers and absent in ten smokers. Smokers with an upper lobe predominance of emphysema (n = 8) had: (1) significantly lower attenuation enhancement values in the upper lobes compared with smokers without emphysema; (2) the lobes with the most severe emphysematous changes had a statistically significantly higher percentage of emphysema (p = 0.0001) and lower mean attenuation enhancement values (p = 0.0001) than the ipsilateral lobes with less severe emphysema, matching parenchymal destruction; (3) a correlation was found between the difference in percentage of emphysema between the upper and lower lobes and the difference in attenuation attenuation enhancement values in the corresponding lobes (p = 0.0355; r = -0.54). Regional alterations of lung perfusion can be depicted by dual-energy CT in smokers with predominant emphysema. |
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Authors:
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Vittorio Pansini; Martine Remy-Jardin; Jean-Baptiste Faivre; Bernhard Schmidt; Alexis Dejardin-Bothelo; Thierry Perez; Valérie Delannoy; Alain Duhamel; Jacques Remy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European radiology Volume: 19 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 2834-43 Citation Subset: IM |
Affiliation:
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Department of Thoracic Imaging, Hospital Calmette, University Center of Lille, Lille, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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