| Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI. | |
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MedLine Citation:
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PMID: 20887325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Gd-EOB-DTPA (gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid) is a gadolinium-based hepatocyte-specific contrast agent for magnetic resonance imaging (MRI). The aim of this study was to determine whether the hepatic uptake and excretion of Gd-EOB-DTPA differ between patients with primary biliary cirrhosis (PBC) and healthy controls, and whether differences could be quantified. METHODS: Gd-EOB-DTPA-enhanced liver MRI was performed in 20 healthy volunteers and 12 patients with PBC. The uptake of Gd-EOB-DTPA was assessed using traditional semi-quantitative parameters (C(max) , T(max) and T(1/2) ), as well as model-free parameters derived after deconvolutional analysis (hepatic extraction fraction [HEF], input-relative blood flow [irBF] and mean transit time [MTT]). In each individual, all parameters were calculated for each liver segment and the median of the segmental values was used to define a global liver median (GLM). RESULTS: Although the PBC patients had relatively mild disease according to their Model for End-stage Liver Disease (MELD), Child-Pugh and Mayo risk scores, they had significantly lower HEF and shorter MTT values compared with the healthy controls. These differences significantly increased with increasing MELD and Child-Pugh scores. CONCLUSIONS: Dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) has a potential role as an imaging-based liver function test. The high spatial resolution of MRI enables hepatic function to be assessed on segmental and sub-segmental levels. |
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Authors:
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Henrik Nilsson; Lennart Blomqvist; Lena Douglas; Anders Nordell; Eduard Jonas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: HPB : the official journal of the International Hepato Pancreato Biliary Association Volume: 12 ISSN: 1477-2574 ISO Abbreviation: HPB (Oxford) Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-03-25 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 100900921 Medline TA: HPB (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 567-76 Citation Subset: IM |
Copyright Information:
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© 2010 International Hepato-Pancreato-Biliary Association. |
Affiliation:
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Department of Clinical Sciences, Karolinska Institutet, Stockholm, Sweden. henrik.nilsson@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Flow Velocity Case-Control Studies Contrast Media / diagnostic use* Female Gadolinium DTPA / diagnostic use* Humans Image Interpretation, Computer-Assisted Liver / blood supply, physiopathology* Liver Circulation Liver Cirrhosis, Biliary / diagnosis*, physiopathology Liver Function Tests* Magnetic Resonance Imaging* Male Middle Aged Perfusion Imaging* Predictive Value of Tests Severity of Illness Index Sweden Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/gadolinium ethoxybenzyl DTPA; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
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