Document Detail

Assessment of left ventricular regional work under ischemia.
MedLine Citation:
PMID:  2288889     Owner:  NLM     Status:  MEDLINE    
The wall tension-regional area (T-A) loop method, a new approach assessing regional contractile function of the left ventricle, has been developed in experiments performed on the isolated dog heart. Regional work is quantitatively determined by the area within a T-A loop with physically correct dimensions of energy (Joule) and regional contractility can be reliably assessed by the end-systolic T-A relation (ESTAR). During global ischemia, both the T-A loop area and the slope of the linear ESTAR decreased in proportion to the decreases in left ventricular stroke work and contractility. During regional ischemia, the T-A loop area in an ischemic region decreased to near zero, and the ESTAR markedly shifted to the right with a decreased slope and an increased regional area intercept. In contrast, the T-A loop in a non-ischematic region showed an increase in systolic area shrinkage and a decrease in regional work, demonstrating hyperkinesis due to regional afterload reduction. In addition, the ESTAR in a non-ischemic region remained almost unchanged. Thus, using the T-A loop method we can reliably assess regional work and contractility of a left ventricular region under ischemia.
Y Goto; S Futaki; Y Ohgoshi; H Yaku; O Kawaguchi; H Suga
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering     Volume:  2     ISSN:  0921-3775     ISO Abbreviation:  Front Med Biol Eng     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-01     Completed Date:  1991-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9011464     Medline TA:  Front Med Biol Eng     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  IM    
Department of Cardiovascular Dynamics, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Biomedical Engineering
Coronary Disease / physiopathology*
Heart Ventricles / physiopathology
Hyperkinesis / physiopathology
Myocardial Contraction / physiology*

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