Document Detail


Assessment of left ventricular pre-ejection period in the fetus using simultaneous magnetocardiography and echocardiography.
MedLine Citation:
PMID:  20975278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Fetal magnetocardiography (fMCG) is a promising new technique for assessing fetal rhythm; however, no prior studies have utilized fMCG to evaluate human fetal electromechanical physiology. Pre-ejection period (PEP) is an important measure of the electromechanical activation of the heart, and is altered by disease states and arrhythmias.
MATERIALS AND METHODS: A novel technique was used to assess fetal PEP and its relationship to other fetal systolic time intervals, RR interval, and gestational age (GA). 25 normal human fetuses between 19 and 38 weeks' gestation were studied using simultaneous pulsed Doppler ultrasound and fMCG. Correlations among PEP, ejection time, QRS width and RR interval were assessed using linear regression.
RESULTS: Across all subjects, PEP was found to correlate with GA (R = 0.57, p < 0.0001), QRS width (R = 0.35, p = 0.026), and RR interval (R = 0.37, p = 0.018). In individual sessions, PEP negatively correlated beat-to-beat with the preceding RR interval.
CONCLUSION: PEP exhibits developmental trends that provide a better understanding of the normal development of the human fetal heart.
Authors:
Nana Aba Mensah-Brown; Ronald T Wakai; Bageshree Cheulkar; Shardha Srinivasan; Janette F Strasburger
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-26
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  28     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-26     Completed Date:  2011-02-10     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  167-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Echocardiography, Doppler*
Female
Fetal Heart / physiology,  ultrasonography*
Gestational Age
Heart Rate, Fetal*
Heart Ventricles / growth & development,  ultrasonography*
Humans
Magnetocardiography*
Pregnancy
Stroke Volume*
Systole / physiology
Ventricular Function*
Grant Support
ID/Acronym/Agency:
R01 HL063174/HL/NHLBI NIH HHS; R01 HL063174-08/HL/NHLBI NIH HHS; R01 HL063174-09A1/HL/NHLBI NIH HHS; R01 HL063174-10/HL/NHLBI NIH HHS; R01HL63174/HL/NHLBI NIH HHS; R21HD049022/HD/NICHD NIH HHS
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