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Assessment of left ventricular dyssynchrony in patients with psoriasis.
MedLine Citation:
PMID:  25219512     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Psoriasis is an inflammatory disorder, which has been reported to be associated with cardiovascular (CV) risks. Although increased CV risks in psoriasis are well established, there are no data about changes of contraction synchrony in psoriasis. Therefore, we aimed to study the left ventricular (LV) contraction synchrony in patients with psoriasis with narrow QRS and normal ejection fraction.
METHODS: Fifty patients with psoriasis and 50 age- and sex-matched control subjects were included in the study. LV dyssynchrony was investigated by color-coded tissue Doppler imaging.
RESULTS: In the psoriasis group, the mean high-sensitive C-reactive protein values were significantly higher compared with the controls. Peak A velocity, deceleration time, isovolumetric relaxation time, and E/E' values were higher in the psoriasis group; however, E/A ratio and average Em were higher in the control group. LV systolic dyssynchrony parameters [including standard deviation of Ts of the 12 LV segments (Ts-SD-12), maximal difference in Ts between any two of the 12 LV segments, standard deviation of Ts of the six basal LV segments, and maximal difference in Ts between any two of the six basal LV segments] were found to be higher in the psoriasis group. The patients with ventricular dyssynchrony (a Ts-SD-12 >34.4 ms) were higher in the psoriasis group than the control group (34% vs. 6%, P < 0.01).
CONCLUSION: In patients with psoriasis with normal ejection fractions and narrow QRS, LV systolic dyssynchrony is an early manifestation of heart involvement and may coexist with diastolic dysfunction.
Authors:
Bilge Bulbul Sen; Emine Nur Rifaioglu; Ozlem Ekiz; Eyup Buyukkaya; Mustafa Kurt; Mehmet Fatih Karakas; Sule Buyukkaya; Perihan Bilen; Adnan Burak Akcay; Nihat Sen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  53     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-09-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1221-7     Citation Subset:  IM    
Copyright Information:
© 2014 The International Society of Dermatology.
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