| Assessment of left ventricular diastolic function and Tei index by tissue Doppler imaging in patients with Cushing's Syndrome. | |
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MedLine Citation:
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PMID: 18269563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to assess left ventricular (LV) function and the Tei index by tissue Doppler imaging (TDI), and also to evaluate the relationship of serum cortisol level with the Tei index and LV function in patients with Cushing's Syndrome (CS). METHODS: We prospectively evaluated 22 patients with CS and 23 control subjects. LV function was assessed by echocardiography. Early diastolic (Em), late diastolic (Am), peak systolic (Sm), mitral annular velocities, Em/Am, the Tei index, and E/Em were calculated by TDI. Mitral inflow velocities, color M-mode flow propagation velocity (Vp), relative wall thickness (RWT), and LV mass index (LVMI) were assessed by two-dimensional echocardiography. RESULT: Peak (E) velocity and the ratio of E to peak late (A) velocity (E/A) were lower in those with CS than in those without. Patients with CS had significantly higher RWT, IVRT, and LVMI than those controls. Vp was lower in the CS-patients than that in control subjects. Em and Em/Am were lower in patients with CS than those in controls. In patients with CS, the Tei index was significantly higher than control subjects. CONCLUSION: Serum cortisol level was positively correlated with the Tei index and E/Em ratio but negatively correlated with Em, Sm, and EF only in patients with CS. Serum cortisol level positively correlated with the Tei index and E/Em ratio but negatively correlated with Em, EF, and Sm. The parameters obtained from lateral mitral annulus by TDI can be used for identification of LV diastolic dysfunction in patients with CS. |
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Authors:
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Merih Baykan; Cihangir Erem; Omer Gedikli; Arif Hacihasanoglu; Turan Erdogan; Mustafa Kocak; Sahin Kaplan; Abdulkadir Kiriş; Cihan Orem; Sükrü Celik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 25 ISSN: 0742-2822 ISO Abbreviation: Echocardiography Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-13 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 182-90 Citation Subset: IM |
Affiliation:
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KTU Faculty of Medicine, Departments of Cardiology, Trabzon-Turkey. merihbaykan@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Case-Control Studies Chi-Square Distribution Cushing Syndrome / blood, physiopathology* Diastole Echocardiography, Doppler* Female Humans Hydrocortisone / blood Male Prospective Studies Ventricular Dysfunction, Left / blood, physiopathology*, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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