| Assessment of iron overload with T2* magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 22014495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T2* is a magnetic relaxation property of any tissue and is inversely related to intracellular iron stores. Measurement is simple, quick, and robust and has high reproducibility. The ability to measure ventricular function plus T2* in the heart and liver during the same scan has revolutionized the understanding of iron storage disease and the management of the iron-loaded patient. The early findings using T2* challenged conventional teachings, and both the technique and the findings were initially viewed with scepticism. However, after a decade of work in validating, calibrating, and expanding access to this method, it is now accepted as the method of choice for tissue iron assessment. In the UK, where T2* measurement was first used in the clinical care of patients with thalassemia major, a large and significant fall in mortality has been seen in this patient group. |
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Authors:
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Lisa J Anderson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Progress in cardiovascular diseases Volume: 54 ISSN: 1532-8643 ISO Abbreviation: Prog Cardiovasc Dis Publication Date: 2011 Nov-Dec |
Date Detail:
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Created Date: 2011-10-21 Completed Date: 2011-12-06 Revised Date: 2012-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0376442 Medline TA: Prog Cardiovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 287-94 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cardiology, St George's University of London, Tooting, London, UK. lisa.anderson@stgeorges.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiomyopathies
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diagnosis*,
metabolism,
physiopathology Humans Iron / metabolism* Iron Overload / diagnosis*, metabolism, physiopathology Magnetic Resonance Imaging* Myocardium / metabolism* Predictive Value of Tests Prognosis Severity of Illness Index Thalassemia / diagnosis*, metabolism, physiopathology |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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