Document Detail

Assessment of iron overload with T2* magnetic resonance imaging.
MedLine Citation:
PMID:  22014495     Owner:  NLM     Status:  MEDLINE    
T2* is a magnetic relaxation property of any tissue and is inversely related to intracellular iron stores. Measurement is simple, quick, and robust and has high reproducibility. The ability to measure ventricular function plus T2* in the heart and liver during the same scan has revolutionized the understanding of iron storage disease and the management of the iron-loaded patient. The early findings using T2* challenged conventional teachings, and both the technique and the findings were initially viewed with scepticism. However, after a decade of work in validating, calibrating, and expanding access to this method, it is now accepted as the method of choice for tissue iron assessment. In the UK, where T2* measurement was first used in the clinical care of patients with thalassemia major, a large and significant fall in mortality has been seen in this patient group.
Lisa J Anderson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  54     ISSN:  1873-1740     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-10-21     Completed Date:  2011-12-06     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-94     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Cardiology, St George's University of London, Tooting, London, UK.
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MeSH Terms
Cardiomyopathies / diagnosis*,  metabolism,  physiopathology
Iron / metabolism*
Iron Overload / diagnosis*,  metabolism,  physiopathology
Magnetic Resonance Imaging*
Myocardium / metabolism*
Predictive Value of Tests
Severity of Illness Index
Thalassemia / diagnosis*,  metabolism,  physiopathology
Reg. No./Substance:

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