| Assessment of invasive growth pattern and lymphocytic infiltration in colorectal cancer. | |
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MedLine Citation:
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PMID: 8803598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 122 specimens of colorectal cancer were re-assessed in relation to the reporting of invasive growth pattern (expanding vs. infiltrating) and presence or absence of peritumoral lymphocytic infiltrate as used in the Jass prognostic classification. Jass agreed with 69% of cases reported as infiltrating and 90% of reported as expanding. This parameter was distributed similarly amongst Dukes B and C cases in the original assessment (P = 0.27), whereas in the reviewed data infiltrating cases were more likely to be staged as Dukes C (P = 0.04). Jass agreed with 44% of lymphocyte present and 94% of lymphocyte absent assessments. The original lymphocyte assessments showed no significant differences in distribution between Dukes A and B cases (P = 0.12) or B and C cases (P = 0.75), whereas the reviewed data showed significant differences for A vs. B (P = 0.015) and B vs. C cases (P = 0.0025). Criteria for assessment were circulated to eight observers who revisited 20 of the cases in which there was disagreement. Consensus agreement with Jass was achieved in nine of 10 cases for invasive growth pattern and seven of 10 cases for lymphocyte infiltration (with two being evenly split). Most observers showed at least fair levels of agreement with Jass and some achieved excellent levels of agreement. This study indicates that assessment of criteria used in the Jass prognostic system for colorectal cancer is less than optimal in routine practice, but is improved through the provision of simple guidelines. |
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Authors:
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J R Jass; Y Ajioka; J P Allen; Y F Chan; R J Cohen; J M Nixon; M Radojkovic; A P Restall; S R Stables; L J Zwi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histopathology Volume: 28 ISSN: 0309-0167 ISO Abbreviation: Histopathology Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-12-19 Completed Date: 1996-12-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 543-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Colorectal Neoplasms
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pathology* Evaluation Studies as Topic Humans Lymphocytes, Tumor-Infiltrating / pathology* Neoplasm Invasiveness / pathology* Observer Variation Retrospective Studies |
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