Document Detail


Assessment of intragastric pH value changes after early nasogastric feeding.
MedLine Citation:
PMID:  10978856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies have suggested that early feeding after injury decreases morbidity and mortality. Few reports, however, have focused on the change in pH inside the stomach after early tube feeding. The aim of the present study was the assessment of 1) the change in intragastric pH after surgery, and 2) the effect of early nasogastric tube feeding on intragastric pH value. From April 1997 to February 1998, 80 patients who underwent colon resection for colorectal cancer by a single surgeon entered the study and were randomized into four groups. Twenty patients (group I) were kept on NPO for 1 wk, and 20 patients per group (groups II, III, and IV) were fed through a nasogastric tube from the second to the seventh postoperative day with low-residual (Osmolite HN), high-fat (Pulmocare), and glutamine-containing (AlitraQ) enteral formulas. Feeding started at 500 kcal/500 cc/d. If the patient tolerated the formula well, feeding increased to 1500 kcal/1500 cc(-1)/d(-1) the following day. Intragastric pH was measured preoperatively and then twice daily until the sixth postoperative day. The pH value of intragastric juice increased significantly once feeding started (3. 67 +/- 1.33 on the third postoperative day; 4.28 +/- 1.26 on the six postoperative day). The pH value seemed only mildly affected by the patient's tolerance for tube feeding (poorly tolerated group, pH 3. 52 +/- 1.75 versus 3.75 +/- 1.21 in the well-tolerated group on the third postoperative day; poorly tolerated group, pH 3.67 +/- 1.02 versus 4.45 +/- 1.27 in the well-tolerated group on the sixth postoperative day). The pH value of intragastric juice was higher in group II than in groups III and IV (4.51 +/- 1.57, 3.90 +/- 1.20, 4. 42 +/- 0.89 respectively, on the sixth postoperative day). This series suggests that early nasogastric feeding can significantly elevate the intragastric pH value in patients after resection of colorectal cancer. Nasogastric feeding may decrease the incidence of stress ulceration by elevating the pH value of intragastric juice.
Authors:
T C Hsu; S C Leu; C F Su; P C Huang; L F Tsai; S L Tsai
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  16     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-12     Completed Date:  2000-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  751-4     Citation Subset:  IM    
Affiliation:
Nutrition Support Service, Mackay Memorial Hospital, Taipei, Taiwan. Tzu.Hsu@Ln.ssw.abbott.com
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MeSH Terms
Descriptor/Qualifier:
Carbohydrates
Caseins
Colon / surgery
Colorectal Neoplasms / surgery
Enteral Nutrition*
Food, Formulated
Gastric Juice / chemistry
Humans
Hydrogen-Ion Concentration
Intubation, Gastrointestinal*
Lipids
Postoperative Period
Preoperative Care
Stomach*
Vegetable Proteins
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Caseins; 0/Lipids; 0/Vegetable Proteins; 102257-18-1/Osmolite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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