Document Detail

Assessment of intestinal absorption of trace metals in humans by means of stable isotopes.
MedLine Citation:
PMID:  12219989     Owner:  NLM     Status:  MEDLINE    
This study is aimed to demonstrate the feasibility of stable isotopes for the assessment of reliable data on fractional intestinal absorption of trace metals in healthy humans. Among the various methods available, the double isotope technique, i.e. one isotope given orally together with the test substance to be investigated and another isotope injected intravenously to correct for retention and endogenous excretion of the particular trace metal, provides quantitative figures of intestinal absorption at reasonable expenses with regard to costs for materials and number of samples to be evaluated. The trace metals exemplarily included in this study, i.e. iron, cobalt and molybdenum show diverging relations between absorbed fractions and amounts administered which are indicative for different regulatory mechanisms of their body content. Food ligands influence the fractional absorption significantly so that the uptake from a composite meal cannot be derived from results on uptake from particular foodstuffs. Therefore, validated data on the behaviour of intestinal absorption will significantly contribute to a better understanding of human trace metal metabolism.
E Werner; P Roth; V Höllriegl; Ch Hansen; J P Kaltwasser; A Giussani; M C Cantone; H Greim; T Zilker; N Felgenhauer
Related Documents :
2560609 - Inhibitors of copper bioutilization: fiber, lead, phytate and tannins.
11341289 - The relationship of dissolved pb to some dissolved trace metals (al, cr, mn, and zn) an...
9599459 - Non-occupational exposure of adult women in manila, the philippines, to lead and cadmium.
24042039 - Effects of acute intermittent hypoxia on energy balance and hypothalamic feeding pathways.
16700589 - Photocatalytic reduction of an azide-terminated self-assembled monolayer using cds quan...
23981269 - Nitrogen conservation and acidity control during food wastes composting through struvit...
15611239 - Ctla-4 signaling regulates the intensity of hypersensitivity responses to food antigens...
20713399 - Globalization's effects on world agricultural trade, 1960-2050.
2299229 - Development of inductive heating equipment using an inductive aperture-type applicator.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Isotopes in environmental and health studies     Volume:  38     ISSN:  1025-6016     ISO Abbreviation:  Isotopes Environ Health Stud     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2003-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9602611     Medline TA:  Isotopes Environ Health Stud     Country:  England    
Other Details:
Languages:  eng     Pagination:  23-31     Citation Subset:  IM    
GSF-National Research Center for Environment and Health, Institute of Radiation Protection, Oberschleissheim, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Intestinal Absorption*
Metals / pharmacokinetics*
Reg. No./Substance:
0/Isotopes; 0/Metals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Variations of lead isotopes and airborne particulate concentrations from the Kozani basin, West Mace...
Next Document:  Bioaccumulation of 65Zn2+ ions by some hydrophytic plants.