Document Detail


Assessment of intestinal absorption of trace metals in humans by means of stable isotopes.
MedLine Citation:
PMID:  12219989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study is aimed to demonstrate the feasibility of stable isotopes for the assessment of reliable data on fractional intestinal absorption of trace metals in healthy humans. Among the various methods available, the double isotope technique, i.e. one isotope given orally together with the test substance to be investigated and another isotope injected intravenously to correct for retention and endogenous excretion of the particular trace metal, provides quantitative figures of intestinal absorption at reasonable expenses with regard to costs for materials and number of samples to be evaluated. The trace metals exemplarily included in this study, i.e. iron, cobalt and molybdenum show diverging relations between absorbed fractions and amounts administered which are indicative for different regulatory mechanisms of their body content. Food ligands influence the fractional absorption significantly so that the uptake from a composite meal cannot be derived from results on uptake from particular foodstuffs. Therefore, validated data on the behaviour of intestinal absorption will significantly contribute to a better understanding of human trace metal metabolism.
Authors:
E Werner; P Roth; V Höllriegl; Ch Hansen; J P Kaltwasser; A Giussani; M C Cantone; H Greim; T Zilker; N Felgenhauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Isotopes in environmental and health studies     Volume:  38     ISSN:  1025-6016     ISO Abbreviation:  Isotopes Environ Health Stud     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2003-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9602611     Medline TA:  Isotopes Environ Health Stud     Country:  England    
Other Details:
Languages:  eng     Pagination:  23-31     Citation Subset:  IM    
Affiliation:
GSF-National Research Center for Environment and Health, Institute of Radiation Protection, Oberschleissheim, Germany. eckhard.werner@gsf.de
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Intestinal Absorption*
Isotopes*
Male
Metals / pharmacokinetics*
Chemical
Reg. No./Substance:
0/Isotopes; 0/Metals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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