Document Detail

Assessment of interventricular dyssynchrony by real time three-dimensional echocardiography: an in vitro study in a porcine model.
MedLine Citation:
PMID:  20653763     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Loss of synchronous contraction between or within the right and left ventricle (RV, LV) leads to adverse ventricular function. We used real time three-dimensional echocardiography (RT3DE) for evaluation of severity of interventricular dyssynchrony and function in a porcine heart model.
METHODS: Six fresh in vitro porcine hearts were used to create a controlled model of LV and RV dyssynchrony using two sets of pulsatile pumps. Synchronized and dyssynchronized pump settings were used with two different dyssynchronized settings: LV filled first and RV filled first.
RESULTS: There was good correlation between actual measurement and RT3DE for interventricular time difference (r = 0.95, P < 0.0001) and stroke volume (SV) for LV and RV (0.89, 0.85; P < 0.0001, respectively). RT3DE data showed a small but significant underestimation for actual volume (P < 0.05). The intra- and interobserver variabilities are 2.9 +/- 1.5% and 3.1 +/- 5.4% for LV and RV SVs, and 1.7 +/- 2.4% and 2.2 +/- 3.2% for time differences by RT3DE. There was significant difference in RV SV between synchrony and dyssynchrony when the RV filled first (P < 0.05), but not in other groups. The same pattern was found in RT3DE derived SVs (synchrony versus dyssynchrony with RV filled first, P < 0.05).
CONCLUSIONS: There is no compromise in LV SV during interventricular dyssynchrony; but RV SV was significantly diminished when the RV filled first. RT3DE is a feasible, robust and reproducible method to identify interventricular dyssynchrony and to evaluate ventricular SVs.
Minjuan Zheng; Xiaokui Li; Pengyuan Zhang; Weihui Shentu; Muhammad Ashraf; Galym Imanbayev; Cole Streiff; Shuping Ge; David J Sahn
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  27     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  709-15     Citation Subset:  IM    
Oregon Health & Science University, Portland, Oregon 97239-3098, USA.
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MeSH Terms
Computer Systems
Disease Models, Animal*
Echocardiography, Three-Dimensional / methods*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Reproducibility of Results
Sensitivity and Specificity
Ventricular Dysfunction, Left / complications,  ultrasonography*
Ventricular Dysfunction, Right / complications,  ultrasonography*

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