| Assessment of intermediate stenosis in the left anterior descending coronary artery with contrast-enhanced transthoracic Doppler echocardiography. | |
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MedLine Citation:
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PMID: 12702929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Visual or quantitative assessment of coronary angiography may not exactly predict the physiological significance of intermediate (40-70%) coronary stenosis. Coronary flow reserve is a well-established marker of the functional significance of coronary stenosis. OBJECTIVES: The aim of this study was to compare the coronary flow velocity reserve (CFVR) using contrast-enhanced transthoracic Doppler echocardiography (CE-TTDE) with thallium-201 imaging in assessment of intermediate lesions in the left anterior descending coronary artery (LAD). METHODS: A consecutive series of 50 patients with intermediate stenosis in the LAD underwent pharmacological stress thallium-201 imaging and CFVR measured by CE-TTDE. RESULTS: CFVR could be measured in 49 of 50 patients by the present method. A CFVR <2.0 predicted the presence of a stress thallium defect in 12 of 14 patients (agreement=90%, kappa=0.76, P < 0.001). The sensitivity and specificity of CFVR for stress thallium-201 results were 86 and 91%, respectively. In contrast, significant stenosis (>50% by diameter) showed fair agreement for stress thallium defects (agreement=59%, kappa=0.28, P < 0.05). CONCLUSIONS: In the evaluation of intermediate lesions in the LAD, CFVR as assessed by CE-TTDE could accurately predict the presence of ischemia on stress thallium imaging, whereas angiographic stenosis did not yield reliable results. |
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Authors:
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Hideki Okayama; Takumi Sumimoto; Go Hiasa; Kazuhisa Nishimura; Norikatsu Morioka; Kouzo Yamamoto; Hiroyuki Kawada |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Coronary artery disease Volume: 14 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-18 Completed Date: 2003-09-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: England |
Other Details:
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Languages: eng Pagination: 247-54 Citation Subset: IM |
Affiliation:
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Department of Carediology, Kitaishikai Hospital, 2632-3 Tokunomori, Ozu, Ehime 795-0061, Japan. hiokayam@sea.plala.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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diagnostic use Aged Arteries / physiopathology, radionuclide imaging, ultrasonography Blood Flow Velocity / physiology Coronary Angiography Coronary Circulation / physiology Coronary Stenosis / diagnosis*, epidemiology, physiopathology Coronary Vessels / physiopathology, radionuclide imaging, ultrasonography Echocardiography* Echocardiography, Doppler / methods Female Follow-Up Studies Humans Image Enhancement* Infusions, Intravenous Male Middle Aged Observer Variation Sensitivity and Specificity Severity of Illness Index Thallium Radioisotopes / diagnostic use Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Thallium Radioisotopes; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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