Document Detail

Assessment of intakes and doses to workers followed for 15 years after accidental inhalation of 60CO.
MedLine Citation:
PMID:  17351497     Owner:  NLM     Status:  MEDLINE    
Intakes and doses are assessed for seven workers who accidentally inhaled particles containing Co in the same incident. Comprehensive whole body data to 15 y, and some early urine and fecal data, are available for each individual. The biokinetic and dosimetric models currently recommended by ICRP have been used to assess these cases. It was not possible to obtain good fits to the data using the ICRP models with their default parameter values. However, good fits to all the measurement data were obtained by varying parameter values following a procedure similar to that recommended in recently developed guidelines for assessment of internal doses from monitoring data. It was found that retention in the lungs was much longer than predicted by the ICRP Human Respiratory Tract Model, and so for each case it was necessary to reduce the particle transport clearance of material from the deep lungs. This reduction in lung clearance rates, and the use of specific AMAD values, were the dominating factors in changing assessed doses from those calculated using ICRP default values.
K Davis; J W Marsh; M Gerondal; M R Bailey; B Le Guen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Health physics     Volume:  92     ISSN:  0017-9078     ISO Abbreviation:  Health Phys     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-44     Citation Subset:  IM    
Radiation Protection Division, Health Protection Agency (HPA), Chilton, Didcot, Oxon OX11 0RQ, UK.
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MeSH Terms
Accidents, Occupational*
Air Pollutants, Radioactive / pharmacokinetics*,  toxicity
Cobalt Radioisotopes / pharmacokinetics*,  toxicity
Dose-Response Relationship, Radiation
Inhalation Exposure*
Lung / metabolism,  radiation effects*
Organ Specificity / physiology,  radiation effects*
Retrospective Studies
Risk Assessment
Time Factors
Reg. No./Substance:
0/Air Pollutants, Radioactive; 0/Cobalt Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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