Document Detail

Assessment of infant brain development with frequency-domain near-infrared spectroscopy.
MedLine Citation:
PMID:  17413855     Owner:  NLM     Status:  MEDLINE    
This is the first report to demonstrate quantitative monitoring of infant brain development with frequency-domain near-infrared spectroscopy (FD-NIRS). Regionally specific increases in blood volume and oxygen consumption were measured in healthy infants during their first year. The results agree with prior PET and SPECT reports; but, unlike these methods, FD-NIRS is portable and uses nonionizing radiation. Further, new information includes the relatively constant tissue oxygenation with age and location, suggesting a tight control between local oxygen delivery and consumption in healthy infants during brain development. FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development.
Maria Angela Franceschini; Sonal Thaker; George Themelis; Kalpathy K Krishnamoorthy; Heather Bortfeld; Solomon G Diamond; David A Boas; Kara Arvin; P Ellen Grant
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  61     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-07-16     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
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MeSH Terms
Brain / anatomy & histology,  growth & development*,  physiology*
Cerebrovascular Circulation
Oxygen Consumption
Regional Blood Flow
Spectroscopy, Near-Infrared / methods*
Grant Support
K23 NS042758/NS/NINDS NIH HHS; K23 NS042758-05/NS/NINDS NIH HHS; K23 NS42758/NS/NINDS NIH HHS; R01 HD042908/HD/NICHD NIH HHS; R01 HD042908-03/HD/NICHD NIH HHS; R01 HD042908-04/HD/NICHD NIH HHS; R01 HD042908-05A1/HD/NICHD NIH HHS; R01-HD42908/HD/NICHD NIH HHS

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