| Assessment of imaging techniques for evaluating small-airway disease in asthma. | |
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MedLine Citation:
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PMID: 21742230 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The imaging techniques used to investigate patients with asthma and to assess the effects of asthma treatments include computed tomography (CT), helium magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron-emission tomography (PET). Only MRI does not involve radiation exposure. Technical improvements in CT, together with the imaging advantages inherent in the presence of air in the lung, have diminished the radiation exposure required for lung CT. High-resolution low-dose lung CT protocols deliver a dose roughly equal to 1 year of natural radiation exposure and can be used even in paediatric patients. To date, CT is the most extensively studied lung imaging method, the simplest to perform, and the least expensive. In patients with asthma, CT may show several structural changes related to small-airway disease including cylindrical bronchiolectasis, bronchial wall thickening, and air trapping; an indirect marker for bronchiolar obstruction. A robust body of evidence indicates that valid CT markers for small-airway disease can be derived from quantitative lung density measurements and that these markers correlate with clinical severity and lung function test results. In addition, these CT markers are sufficiently sensitive to demonstrate therapeutic effects. |
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Authors:
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F Laurent; M Tunon de Lara |
Publication Detail:
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Type: Journal Article Date: 2011-06-08 |
Journal Detail:
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Title: Revue des maladies respiratoires Volume: 28 ISSN: 1776-2588 ISO Abbreviation: Rev Mal Respir Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8408032 Medline TA: Rev Mal Respir Country: France |
Other Details:
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Languages: eng Pagination: e7-e10 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 SPLF. Published by Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Institut national de la Santé et de la recherche médicale, Inserm U1046, université Victor-Segalen Bordeaux 2, hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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