Document Detail

Assessment of hypoxia in children with cystic fibrosis.
MedLine Citation:
PMID:  16243867     Owner:  NLM     Status:  MEDLINE    
Hypoxia during sleep and exercise may occur in an important number of patients with cystic fibrosis (CF). Despite its recognition, no clear definition for hypoxia in CF exists, and nor do guidelines for commencing oxygen therapy. CF patients with hypoxia may have increased pulmonary artery pressure, reduced exercise ability, and skeletal muscle strength, and most importantly of all worse sleep quality, and a worse quality of life. Laboratory and rodent evidence exists to suggest that hypoxia may contribute to the decline in lung function in CF by upregulating lung inflammation, and encouraging growth of Pseudomonas aeruginosa, the most important pathogen associated with CF lung disease. The effects of hypoxia in childhood CF need to be fully studied, and a potential expanded role for oxygen as therapy in CF may be worthy of exploration.
D S Urquhart; H Montgomery; A Jaffé
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  90     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-24     Completed Date:  2005-11-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  1138-43     Citation Subset:  AIM; IM    
Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health, and Great Ormond Street Hospital for Children NHS Trust, London, UK.
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MeSH Terms
Anoxia / diagnosis,  etiology*,  therapy
Cystic Fibrosis / complications*
Opportunistic Infections / etiology
Oxygen Inhalation Therapy
Pneumonia / etiology
Pulmonary Circulation
Quality of Life

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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