Document Detail


Assessment of human exposure to copper: a case study using the NHEXAS database.
MedLine Citation:
PMID:  16249795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Copper is an essential trace element and adverse health effects can potentially be associated with both very low and very high intakes. Accurate estimates of inhalation and ingestion (food and drinking water) exposures are therefore needed in order to realistically assess any effects of the distribution of copper intakes within the general population. The work presented here demonstrates an application of a customized subset of the MENTOR/SHEDS-4M computational system (Modeling ENvironment for TOtal Risk studies, employing the Stochastic Human Exposure and Dose Simulation approach, for Multimedia, Multipathway, Multiroute exposures to Multiple co-occurring contaminants. The application utilized data from the National Human Exposure Assessment Survey (NHEXAS) for USEPA Region V as well as from a variety of other available databases. The case study, using a statistical population-based modeling framework, was performed for Eaton County, MI. The results of the simulations, aggregated for six age subgroups of the general population, suggest that food intake is the major pathway for total copper exposure, while drinking water can have significant contributions at the tail of the distribution of intakes. Specifically, it was estimated that over 80% of the county population received potential doses of copper from food that were lower than the Institute of Medicine (IOM) Recommended Dietary Allowance (RDA) value of 900 microg/day. Furthermore, the total combined potential dose from food and water was only about two times greater than the recommended value only for individuals with intakes in the range above the 99th percentile of both food and water intakes. The values were well below the upper tolerable intake value of 10,000 microg/day. The inhalation route consistently acted as only a minor contributor to the total exposure.
Authors:
Panos G Georgopoulos; Sheng Wei Wang; Ioannis G Georgopoulos; Mary Jean Yonone-Lioy; Paul J Lioy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2005-10-26
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  16     ISSN:  1559-0631     ISO Abbreviation:  -     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2007-01-09     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-409     Citation Subset:  IM    
Affiliation:
Exposure Measurement and Assessment Division, Environmental and Occupational Health Sciences Institute (EOHSI) (a Joint Institute of UMDNJ- Robert Wood Johnson Medical School and Rutgers University), Piscataway, NJ 08854, USA. panosg@ccl.rutgers.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
Copper / analysis*,  toxicity*
Databases, Factual
Environmental Exposure
Environmental Monitoring / methods*
Food Contamination / analysis*
Humans
Infant
Infant, Newborn
Middle Aged
Water Pollutants / analysis*
Grant Support
ID/Acronym/Agency:
P30ES05022/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Water Pollutants; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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