| Assessment of hemodynamics in precancerous lesion of hepatocellular carcinoma: evaluation with MR perfusion. | |
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MedLine Citation:
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PMID: 17451197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the hemodynamic changes in a precancerous lesion model of hepatocellular carcinoma (HCC). METHODS: Hemodynamic changes in 18 Wistar rats were studied with non-invasive magnetic resonance (MR) perfusion. The changes induced by diethylnitrosamine (DEN) developed into liver nodular lesions due to hepatic cirrhosis during the progression of carcinogenesis. The MR perfusion data [positive enhancement integral (PEI)] were compared between the nodular lesions corresponding well with MR images and pathology and their surrounding hepatic parenchyma. RESULTS: A total of 46 nodules were located by MR imaging and autopsy, including 22 dysplastic nodules (DN), 9 regenerative nodules (RN), 10 early HCCs and 5 overt HCCs. Among the 22 DNs, 6 were low-grade DN (LGDN) and 16 were high-grade DN (HGDN). The average PEI of RN, DN, early and overt HCC was 205.67 +/- 31.17, 161.94 +/- 20.74, 226.09 +/- 34.83, 491.86 +/- 44.61 respectively, and their liver parenchyma nearby was 204.84 +/- 70.19. Comparison of the blood perfusion index between each RN and its surrounding hepatic parenchyma showed no statistically significant difference (P = 0.06). There were significant differences in DN (P = 0.02). During the late hepatic arterial phase, the perfusion curve in DN declined. DN had an iso-signal intensity at the early hepatic arterial phase and a low signal intensity at the portal venous phase. Of the 10 early HCCs, 4 demonstrated less blood perfusion and 6 displayed minimally increased blood flow compared to the surrounding parenchyma. Five HCCs showed significantly increased blood supply compared to the surrounding parenchyma (P = 0.02). CONCLUSION: Non-invasive MR perfusion can detect changes in blood supply of precancerous lesions. |
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Authors:
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Sheng Guan; Wei-Dong Zhao; Kang-Rong Zhou; Wei-Jun Peng; Feng Tang; Jian Mao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 13 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1182-6 Citation Subset: IM |
Affiliation:
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Department of Radiology, 1st Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / diagnosis, physiopathology* Liver Circulation / physiology* Liver Neoplasms / diagnosis, physiopathology* Magnetic Resonance Imaging / methods Male Precancerous Conditions / diagnosis, physiopathology* Rats Rats, Wistar |
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