Document Detail

Assessment of haemolytic and thromboembolic potentials--from CFD studies of Starr-Edwards cardiac valve prostheses.
MedLine Citation:
PMID:  2604624     Owner:  NLM     Status:  MEDLINE    
Quantitative assessments of haemolysis, thromboembolism and endothelial damage are established using computational fluid dynamics and documented threshold values. The régime studied was steady forward (systolic) flow through a fully open Starr-Edwards model 1260 ball valve, in an aortic shaped chamber. Modelling was carried out using finite difference techniques for turbulent, Newtonian flow. Haemolysis was not predicted "in-bulk", but a haemolytic potential as high as 30% was suggested at prosthetic surfaces. Also a 10% thromboembolic potential and a 6% potential for endothelium damage were noted.
G D Tansley; J Mazumdar; B J Noye; I H Craig; K Thalassoudis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine     Volume:  12     ISSN:  0158-9938     ISO Abbreviation:  Australas Phys Eng Sci Med     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-02-06     Completed Date:  1990-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8208130     Medline TA:  Australas Phys Eng Sci Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
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MeSH Terms
Aortic Valve
Endothelium, Vascular / injuries*
Heart Valve Prosthesis / adverse effects*
Models, Statistical*
Reference Values
Thromboembolism / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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