Document Detail

Assessment of gut intraepithelial lymphocytes during late gestation and the neonatal period.
MedLine Citation:
PMID:  7727614     Owner:  NLM     Status:  MEDLINE    
Intraepithelial lymphocyte counts (IEL % enterocytes) were carried out in histological samples of jejunal, ileal and appendiceal mucosa of 39 neonates, aged from birth to 28 days. Correlations between IEL counts and developmental factors, namely gestational age, birth weight and intrauterine growth, as well as neonatal infections or feeding state were performed. No significant differences were observed among neonates grouped according to birth weight, intrauterine growth or neonatal infections. The pattern of feeding, however was associated with significantly higher IEL counts (p < 0.02) in the ileum in oral/enterally fed neonates than in the unfed or parenterally fed. Full-term neonates also had higher counts in the ileum (p < 0.02). In this group, oral/enterally fed neonates had the higher values. Thus, besides in utero development, the pattern of feeding might be considered as an important modulating factor on IEL postnatal expansion.
C S Machado; M A Rodrigues; H V Maffei
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  66     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1994  
Date Detail:
Created Date:  1995-06-01     Completed Date:  1995-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  324-9     Citation Subset:  IM    
Department of Paediatrics, Botucatu School of Medicine, São Paulo, Brazil.
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MeSH Terms
Antigens / metabolism
Appendix / cytology*,  embryology,  physiology
Birth Weight
Embryonic and Fetal Development / physiology
Enteral Nutrition
Epithelial Cells
Epithelium / embryology,  physiology
Fetus / cytology*,  physiology
Gestational Age
Ileum / cytology*,  embryology,  physiology
Infant, Newborn / immunology,  physiology*
Infant, Premature / immunology,  physiology
Intestinal Mucosa / cytology,  embryology,  physiology
Jejunum / cytology*,  embryology,  physiology
Lymphocyte Count
Lymphocytes / cytology*,  physiology
Parenteral Nutrition, Total
Pregnancy Trimester, Third
Reg. No./Substance:

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