Document Detail

Assessment of glomerular filtration rate during pregnancy using the MDRD formula.
MedLine Citation:
PMID:  17970797     Owner:  NLM     Status:  MEDLINE    
It is now recommended practice to use estimated glomerular filtration rate (eGFR) values to screen for and monitor chronic renal disease. The most frequently used formula in the general population is that described following the Modification of Diet in Renal Disease (MDRD) study whereby serum creatinine is adjusted for age, gender and race. This study evaluates the performance of the MDRD formula in pregnancy by comparing eGFR with measured values obtained by inulin clearance studies in early and late normal pregnancy and in pregnancies complicated by renal disease or pre-eclampsia. Our results indicate that in all situations, MDRD substantially underestimates glomerular filtration rate during pregnancy and cannot be recommended for use in clinical practice.
M C Smith; P Moran; M K Ward; J M Davison
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-25
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  115     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-01-17     Revised Date:  2008-10-28    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  109-12     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, School of Surgical and Reproductive Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
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MeSH Terms
Creatinine / blood
Glomerular Filtration Rate / physiology*
Kidney Failure, Chronic / physiopathology
Pre-Eclampsia / physiopathology
Pregnancy / physiology*
Pregnancy Complications / physiopathology
Sensitivity and Specificity
Reg. No./Substance:
Comment In:
BJOG. 2008 Aug;115(9):1192; author reply 1193   [PMID:  18715452 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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