Document Detail

Assessment of glomerular charge selectivity in man by differential clearance of isoamylases.
MedLine Citation:
PMID:  7683259     Owner:  NLM     Status:  MEDLINE    
1. Glomerular charge selectivity was assessed using the ratio of the clearance of pancreatic isoamylase to the clearance of the more anionic salivary isoamylase (CPAm/CSAm) in 30 normal subjects, 14 patients with minimal proteinuria and 23 patients with heavy proteinuria due to primary glomerulopathies. Seven patients with minimal change nephropathy were studied in relapse and remission. 2. CPAm/CSAm exceeded 2.0 (range 2.1-6.1) in all normal subjects, indicating that the normal glomerular capillary wall possesses charge selectivity at the molecular size of amylase (molecular mass 56 kDa). 3. CPAm/CSAm was significantly lower in patients with heavy proteinuria than in normal subjects or patients with minimal proteinuria. CPAm/CSAm was low in patients with minimal change nephropathy in relapse and rose into the normal range with steroid-induced remission. 4. These data suggest that heavy proteinuria in primary glomerulopathies is accompanied by loss of glomerular charge selectivity. Remission of minimal change nephropathy is associated with restoration of normal charge selectivity.
J G Fox; J D Quin; D S O'Reilly; J M Boulton-Jones
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  84     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-01     Completed Date:  1993-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  449-54     Citation Subset:  IM    
Renal Unit, Royal Infirmary, Glasgow, U.K.
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MeSH Terms
Amylases / metabolism*
Kidney Diseases / metabolism
Kidney Glomerulus / metabolism*
Metabolic Clearance Rate / physiology
Nephrosis, Lipoid / metabolism
Pancreas / enzymology
Proteinuria / metabolism*
Saliva / enzymology
Reg. No./Substance:
0/Isoenzymes; EC 3.2.1.-/Amylases

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