| Assessment of the global two-stage method to EC50 determination. | |
| | |
MedLine Citation:
|
PMID: 9694169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Preclinical studies of a new drug supply sets of concentration-effect observations. For each experiment, EC50 is estimated through fitting of the Emax model. Naive pooling of these individual estimates, also called the Standard Two-Stage method (STS), is usually performed. A better combination is obtained by the Global Two-Stage method (GTS) which takes into account the variability of the nonlinear regression estimation errors. The performances of STS and GTS are compared on real and simulated data. The results show that GTS performs better than STS in terms of bias or RMSE, especially in case of poorly designed experiments. Degradation of the quality of STS results in simulations appears to be mainly due to some experiments that are usually rejected by experimenters. Such rejections are avoided when using GTS, which hence is particularly suitable for systematic treatment of this kind of data. |
| | |
Authors:
|
F Patron-Bizet; F Mentré; M Genton; C Thomas-Haimez; J Maccario |
Related Documents
:
|
21731529 - A targeted maximum likelihood estimator of a causal effect on a bounded continuous outc... 19930189 - Design and analysis of crossover trials for absorbing binary endpoints. 16324889 - Analysis strategies for a community trial to reduce adolescent atod use: a comparison o... 17003959 - Optimum two-stage designs in case-control association studies using false discovery rate. 21726329 - The effect of a population bottleneck on the evolution of genetic variance/covariance s... 6720989 - Multiexponential, multicompartmental, and noncompartmental modeling. ii. data analysis ... 15769919 - A comparison of the sensitivity of diagnostic criteria for polymyalgia rheumatica. 17716709 - Source apportionment of pm(2.5) and selected hazardous air pollutants in seattle. 2921069 - Nonlinear parameter estimation applied to psychophysically measured impulse responses. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pharmacological and toxicological methods Volume: 39 ISSN: 1056-8719 ISO Abbreviation: J Pharmacol Toxicol Methods Publication Date: 1998 Mar |
Date Detail:
|
Created Date: 1999-05-03 Completed Date: 1999-05-03 Revised Date: 2000-12-18 |
Medline Journal Info:
|
Nlm Unique ID: 9206091 Medline TA: J Pharmacol Toxicol Methods Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 103-8 Citation Subset: IM |
Affiliation:
|
Department of Biostatistics, Institut de Recherches SERVIER, Suresnes, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chemistry, Pharmaceutical
/
methods Dose-Response Relationship, Drug Drug Evaluation, Preclinical / methods* Models, Statistical Muscle Contraction / drug effects Nonlinear Dynamics Observer Variation Saphenous Vein / drug effects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A method to measure dual NK1/NK2-antagonist activity in dogs.
Next Document: Radioimmunoassay of substance P in lung perfusate.