Document Detail

Assessment of global left and right ventricular function using dual-source computed tomography (DSCT) in comparison to MRI: an experimental study in a porcine model.
MedLine Citation:
PMID:  18030198     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to evaluate the ability of retrospectively ECG-gated dual-source computed tomography (DSCT) to assess left (LV) and right ventricular (RV) functional parameters in comparison to 1.5 T magnetic resonance imaging (MRI). MATERIALS AND METHODS: Ten domestic pigs (60 kg) underwent both contrast-enhanced cardiac DSCT and cardiac MRI using standardized examination protocols under general anesthesia. From manually drawn endocardial and epicardial contours, LV and RV end-systolic (ESV) and end-diastolic volume (EDV), stroke volume (SV), ejection fraction (EF), myocardial mass (MM), peak filling rate (PFR), peak ejection rate (PER), time to peak ejection (TPE), and time to peak filling (TPF) were calculated by means of dedicated analysis software. LV and RV functional parameters were analyzed using Bland-Altman plots, Student t test, and Pearson's correlation coefficient. RESULTS: Both left and right ESV and EDV, SV and EF determined with DSCT correlated well with MR imaging results (left, r = 0.98/0.92/0.82/0.98; right, r = 0.90/0.94/0.96/0.94). PER, PFR, TPE, TPF, and MM showed only a moderate to low correlation (left, r = 0.67/0.37/0.23/0.35/0.57; right, r = 0.78/0.69/0.12/0.11/0.44). PER and PFR were significantly underestimated by DSCT when compared with MRI. CONCLUSIONS: Retrospectively ECG-gated DSCT correctly depicts end-systole and can accurately determine LV and RV volumes, SV, and EF in comparison to MRI. DSCT showed a significant underestimation of PER and PFR in comparison to MRI.
Philipp Bruners; Andreas H Mahnken; Christian Knackstedt; Nadja Luhmann; Elmar Spüntrup; Marco Das; Christian Hohl; Joachim E Wildberger; Thomas Schmitz-Rode; Rolf W Günther; Georg Mühlenbruch
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  42     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-21     Completed Date:  2007-12-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  756-64     Citation Subset:  IM    
Applied Medical Engineering, Helmholtz-Institute for Biomedical Engineering, Aachen, Germany.
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MeSH Terms
Heart Ventricles / anatomy & histology*,  radiography*
Magnetic Resonance Imaging / methods*
Models, Animal*
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed / methods*
Ventricular Function, Left / physiology*
Ventricular Function, Right / physiology*

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